Cell wounding and repair in ventilator injured lungs

Richard A. Oeckler, Rolf D. Hubmayr

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Acute lung injury (ALI) is a common, frequently hospital-acquired condition with a high morbidity and mortality. The stress associated with invasive mechanical ventilation represents a potentially harmful exposure, and attempts to minimize deforming stress through low tidal ventilation have proven efficacious. Lung cells are both sensors and transducers of deforming stress, and are frequently wounded in the setting of mechanical ventilation. Cell wounding may be one of the drivers of the innate immunologic and systemic inflammatory response associated with mechanical ventilation. These downstream effects of mechanotransduction have been referred to collectively as "Biotrauma". Our review will focus on cellular stress failure, that is cell wounding, and the mechanisms mediating subsequent plasma membrane repair, we hold that a better mechanistic understanding of cell plasticity, deformation associated remodeling and repair will reveal candidate approaches for lung protective interventions in mechanically ventilated patients. We will detail one such intervention, lung conditioning with hypertonic solutions as an example of ongoing research in this arena.

Original languageEnglish (US)
Pages (from-to)44-53
Number of pages10
JournalRespiratory Physiology and Neurobiology
Volume163
Issue number1-3
DOIs
StatePublished - Nov 30 2008

Keywords

  • Acute lung injury
  • Deformation-induced lipid trafficking
  • Mechanical ventilation
  • Osmotic stress
  • Plasma membrane repair

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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