Cell-mediated therapies to facilitate operational tolerance in liver transplantation

Samia D. Ellias, Ellen L. Larson, Timucin Taner, Scott L. Nyberg

Research output: Contribution to journalArticlepeer-review

Abstract

Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.

Original languageEnglish (US)
Article number4016
JournalInternational journal of molecular sciences
Volume22
Issue number8
DOIs
StatePublished - Apr 2 2021

Keywords

  • Dendritic cells
  • Liver transplantation
  • Mesenchymal cells
  • Operational tolerance
  • Regulatory T cells
  • Transplant immunology

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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