Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. VI. Influence of the MHC on the tissue specificity of cytotoxic T-lymphocyte responses

J. D. Tyler, W. J. Burlingham, C. S. David, D. Steinmuller

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Abstract

Mice of the C3H/He and A non-H-2 backgrounds are disparate from mice of the B10 background for the tissue-restricted, non-H-2 alloantigen of epidermal cells (EC), Epa-1, that is expressed by EC but not by lymphocytes (LC), as well as for a number of other alloantigens of the B10 background that are expressed by both EC and LC, generically referred to as 'lymphocyte/epidermal alloantigens' (LEA). In this study, we compared the ability of various H-2 congenic strains on the C3H or A backgrounds to mount cytotoxic T-lymphocyte (CTL) responses to EC from H-2 compatible mice of the B10 background. High responses to Epa-1 were detected only in the H-2(a) and H-2(k) haplotypes; H-2(b), H-2(o)1, H-2(s), H-2(t)1, and H-2(t)2 haplotypes were nonresponders to Epa-1. High responses to LEA were detected in H-2(a), H-2(b), H-2(s), H-2(t)1, and H-2(t)2 haplotypes; H-2(k) and H-2(o)1 were nonresponsive to LEA. Analysis of the H-2K, I and D region alleles of responders indicates that H-2K(k) is essential for anti-Epa CTL responses, whereas D(d), D(b) or K(s) were all permissive for strong anti-LEA responses. The ability to mount a given CTL response was not associated with differences in I-region alleles. These results are discussed in terms of K/D region products serving as Ir-gene products for CTL and in determining the apparent tissue-specificity of CTL.

Original languageEnglish (US)
Pages (from-to)23-36
Number of pages14
JournalImmunogenetics
Volume16
Issue number1
StatePublished - 1982

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Organ Specificity
Isoantigens
Cytotoxic T-Lymphocytes
Lymphocytes
Haplotypes
Alleles
Inbred C3H Mouse
Genes
epidermal alloantigen 1

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. VI. Influence of the MHC on the tissue specificity of cytotoxic T-lymphocyte responses. / Tyler, J. D.; Burlingham, W. J.; David, C. S.; Steinmuller, D.

In: Immunogenetics, Vol. 16, No. 1, 1982, p. 23-36.

Research output: Contribution to journalArticle

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abstract = "Mice of the C3H/He and A non-H-2 backgrounds are disparate from mice of the B10 background for the tissue-restricted, non-H-2 alloantigen of epidermal cells (EC), Epa-1, that is expressed by EC but not by lymphocytes (LC), as well as for a number of other alloantigens of the B10 background that are expressed by both EC and LC, generically referred to as 'lymphocyte/epidermal alloantigens' (LEA). In this study, we compared the ability of various H-2 congenic strains on the C3H or A backgrounds to mount cytotoxic T-lymphocyte (CTL) responses to EC from H-2 compatible mice of the B10 background. High responses to Epa-1 were detected only in the H-2(a) and H-2(k) haplotypes; H-2(b), H-2(o)1, H-2(s), H-2(t)1, and H-2(t)2 haplotypes were nonresponders to Epa-1. High responses to LEA were detected in H-2(a), H-2(b), H-2(s), H-2(t)1, and H-2(t)2 haplotypes; H-2(k) and H-2(o)1 were nonresponsive to LEA. Analysis of the H-2K, I and D region alleles of responders indicates that H-2K(k) is essential for anti-Epa CTL responses, whereas D(d), D(b) or K(s) were all permissive for strong anti-LEA responses. The ability to mount a given CTL response was not associated with differences in I-region alleles. These results are discussed in terms of K/D region products serving as Ir-gene products for CTL and in determining the apparent tissue-specificity of CTL.",
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