Cell cycle machinery and its alterations in pancreatic cancer

Yusuke Kojima, Reeja S. Maskey, Yuichi Machida

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer is a disease of uncontrolled cell proliferation. Sequencing of the pancreatic cancer genome revealed frequent gene alterations that lead to constitutive proliferation signals and loss of the breaking systems. Cancer cells also display defects in the DNA repair systems, which suggest that compromised genome integrity contributes to the tumorigenesis process. These observations explain many of the abnormal behaviors of cancer cells, yet stopping proliferation of cancer cells remains a difficult task. This chapter will describe misregulation of the cell-cycle machinery in pancreatic cancer and therapeutic options to stop abnormal proliferation. The basic concept of the normal cell cycle will be outlined first, and the mechanisms of DNA repair will be introduced. Next, alterations of the cell cycle and DNA repair systems in pancreatic cancer will be described. Finally, therapeutic opportunities to target the specific alterations in the cell cycle and DNA repair systems in pancreatic cancer will be discussed.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer
PublisherSpringer New York
Pages19-49
Number of pages31
ISBN (Electronic)9781493971930
ISBN (Print)9781493971916
DOIs
StatePublished - Apr 11 2018

Keywords

  • BRCA
  • CDK
  • Cell cycle
  • Checkpoint
  • Cyclin
  • DNA damage
  • DNA repair
  • p53
  • pRB

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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  • Cite this

    Kojima, Y., Maskey, R. S., & Machida, Y. (2018). Cell cycle machinery and its alterations in pancreatic cancer. In Pancreatic Cancer (pp. 19-49). Springer New York. https://doi.org/10.1007/978-1-4939-7193-0_74