Cell and tumor markers’ immunohistochemistry in transitional cell carcinoma of the bladder

Antonio Lopez Beltran, G. A. Croghan, I. Croghan, J. F. Gaeta

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A wide range of cell and tumor markers including the blood group-related isoantigens A, B. 0(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and 0RP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohisto-chemical detection of EMA may provide additional prognostic information in bladder cancer patients.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalUrologia Internationalis
Volume50
Issue number2
DOIs
StatePublished - Jan 1 1993

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Keywords

  • Cancer prognosis
  • Epithelial membrane antigen
  • Immunohistochemistry
  • Transitional cell carcinoma
  • Tumor markers

ASJC Scopus subject areas

  • Urology

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