Cell and tumor markers’ immunohistochemistry in transitional cell carcinoma of the bladder

Antonio Lopez Beltran; G. A. Croghan; I. Croghan; J. F. Gaeta

doi:10.1159/000282453

Cell and tumor markers’ immunohistochemistry in transitional cell carcinoma of the bladder

Antonio Lopez Beltran, G. A. Croghan, I. Croghan, J. F. Gaeta

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A wide range of cell and tumor markers including the blood group-related isoantigens A, B. 0(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and 0RP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohisto-chemical detection of EMA may provide additional prognostic information in bladder cancer patients.

Original language	English (US)
Pages (from-to)	61-64
Number of pages	4
Journal	Urologia Internationalis
Volume	50
Issue number	2
DOIs	https://doi.org/10.1159/000282453
State	Published - 1993

Keywords

Cancer prognosis
Epithelial membrane antigen
Immunohistochemistry
Transitional cell carcinoma
Tumor markers

ASJC Scopus subject areas

Urology

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10.1159/000282453

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title = "Cell and tumor markers{\textquoteright} immunohistochemistry in transitional cell carcinoma of the bladder",

abstract = "A wide range of cell and tumor markers including the blood group-related isoantigens A, B. 0(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and 0RP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohisto-chemical detection of EMA may provide additional prognostic information in bladder cancer patients.",

keywords = "Cancer prognosis, Epithelial membrane antigen, Immunohistochemistry, Transitional cell carcinoma, Tumor markers",

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T1 - Cell and tumor markers’ immunohistochemistry in transitional cell carcinoma of the bladder

AU - Lopez Beltran, Antonio

AU - Croghan, G. A.

AU - Croghan, I.

AU - Gaeta, J. F.

PY - 1993

Y1 - 1993

N2 - A wide range of cell and tumor markers including the blood group-related isoantigens A, B. 0(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and 0RP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohisto-chemical detection of EMA may provide additional prognostic information in bladder cancer patients.

AB - A wide range of cell and tumor markers including the blood group-related isoantigens A, B. 0(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and 0RP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohisto-chemical detection of EMA may provide additional prognostic information in bladder cancer patients.

KW - Cancer prognosis

KW - Epithelial membrane antigen

KW - Immunohistochemistry

KW - Transitional cell carcinoma

KW - Tumor markers

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Cell and tumor markers’ immunohistochemistry in transitional cell carcinoma of the bladder

Abstract

Keywords

ASJC Scopus subject areas

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