Cell and tumor markers' immunohistochemistry in transitional cell carcinoma of the bladder

A. Lopez-Beltran, G. A. Croghan, Ivana T Croghan, J. F. Gaeta

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A wide range of cell and tumor markers including the blood group-related isoantigens A, B, O(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and ORP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p <0.05) with patient survival. We conclude that immunohistochemical detection of EMA may provide additional prognostic information in bladder cancer patients.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalUrologia Internationalis
Volume50
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Transitional Cell Carcinoma
Tumor Biomarkers
Mucin-1
Urinary Bladder
Immunohistochemistry
Urinary Bladder Neoplasms
Survival
Isoantigens
Oncogene Proteins
Blood Group Antigens
Biopsy

Keywords

  • Cancer prognosis
  • Epithelial membrane antigen
  • Immunohistochemistry
  • Transitional cell carcinoma
  • Tumor markers

ASJC Scopus subject areas

  • Urology

Cite this

Cell and tumor markers' immunohistochemistry in transitional cell carcinoma of the bladder. / Lopez-Beltran, A.; Croghan, G. A.; Croghan, Ivana T; Gaeta, J. F.

In: Urologia Internationalis, Vol. 50, No. 2, 1993, p. 61-64.

Research output: Contribution to journalArticle

Lopez-Beltran, A. ; Croghan, G. A. ; Croghan, Ivana T ; Gaeta, J. F. / Cell and tumor markers' immunohistochemistry in transitional cell carcinoma of the bladder. In: Urologia Internationalis. 1993 ; Vol. 50, No. 2. pp. 61-64.
@article{3b127edc65d34f7199a41c556a4880ac,
title = "Cell and tumor markers' immunohistochemistry in transitional cell carcinoma of the bladder",
abstract = "A wide range of cell and tumor markers including the blood group-related isoantigens A, B, O(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and ORP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p <0.05) with patient survival. We conclude that immunohistochemical detection of EMA may provide additional prognostic information in bladder cancer patients.",
keywords = "Cancer prognosis, Epithelial membrane antigen, Immunohistochemistry, Transitional cell carcinoma, Tumor markers",
author = "A. Lopez-Beltran and Croghan, {G. A.} and Croghan, {Ivana T} and Gaeta, {J. F.}",
year = "1993",
language = "English (US)",
volume = "50",
pages = "61--64",
journal = "Urologia Internationalis",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Cell and tumor markers' immunohistochemistry in transitional cell carcinoma of the bladder

AU - Lopez-Beltran, A.

AU - Croghan, G. A.

AU - Croghan, Ivana T

AU - Gaeta, J. F.

PY - 1993

Y1 - 1993

N2 - A wide range of cell and tumor markers including the blood group-related isoantigens A, B, O(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and ORP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p <0.05) with patient survival. We conclude that immunohistochemical detection of EMA may provide additional prognostic information in bladder cancer patients.

AB - A wide range of cell and tumor markers including the blood group-related isoantigens A, B, O(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and ORP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p <0.05) with patient survival. We conclude that immunohistochemical detection of EMA may provide additional prognostic information in bladder cancer patients.

KW - Cancer prognosis

KW - Epithelial membrane antigen

KW - Immunohistochemistry

KW - Transitional cell carcinoma

KW - Tumor markers

UR - http://www.scopus.com/inward/record.url?scp=0027475071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027475071&partnerID=8YFLogxK

M3 - Article

VL - 50

SP - 61

EP - 64

JO - Urologia Internationalis

JF - Urologia Internationalis

SN - 0042-1138

IS - 2

ER -