Celiac sprue: A unique autoimmune disorder

Shadi Rashtak, Eric V. Marietta, Joseph A. Murray

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.

Original languageEnglish (US)
Pages (from-to)593-604
Number of pages12
JournalExpert review of clinical immunology
Volume5
Issue number5
DOIs
StatePublished - Sep 1 2009

Keywords

  • Ataxia
  • Autoimmune
  • Autoimmune biliary cirrhosis
  • Autoimmune hepatitis
  • Celiac sprue
  • Dermatitis herpetiformis
  • Neuropathy
  • Sjögren's syndrome
  • Thyroid disorder
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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