Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia

A Population-Based Case-Control Study

G. Richard Locke, Joseph A Murray, Alan R. Zinsmeister, L. Joseph Melton, Nicholas J. Talley

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Objective: To determine whether undiagnosed celiac disease is associated with irritable bowel syndrome (IBS) or dyspepsia in the community. Subjects and Methods: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota, residents aged 20 to 50 years. All respondents who reported symptoms of dyspepsia or IBS (cases) and all respondents without notable gastrointestinal symptoms (controls) were invited to participate (260 eligible subjects; 150 [58%] were studied). Each respondent was examined by a physician, and the medical records of each were reviewed (3 subjects did not meet the criteria for dyspepsia or IBS at the time of the physician interview). Serum was obtained to measure antiendomysial antibodies and tissue transglutaminase (TTg) IgA antibodies using validated assays. Results: A total of 34 subjects had dyspepsia (20 had ulcerlike dyspepsia), 50 had IBS (19 had diarrhea-predominant IBS), and 15 met criteria for both dyspepsia and IBS; 78 were asymptomatic healthy controls. The overall prevalence of positive TTg serology was 4% (95% confidence interval [CI], 1.5%-8.5%). The number or subjects who were seropositive for TTg was 2 of 34 (5.9%) with dyspepsia (95% CI, 0.7%-19.7%), 2 of 50 (4.0%) with IBS (95% CI, 0.5%-13.7%), and 2 of 78 (2.6%) of asymptomatic controls (95% CI, 0.3%-9.0%) (P=.64 IBS vs controls; P=.58 dyspepsia vs controls). No subjects had positive antiendomysial antibodies. Conclusion: In this community, celiac disease did not explain the presence of either IBS or dyspepsia.

Original languageEnglish (US)
Pages (from-to)476-482
Number of pages7
JournalMayo Clinic Proceedings
Volume79
Issue number4
StatePublished - 2004

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Irritable Bowel Syndrome
Dyspepsia
Celiac Disease
Serology
Case-Control Studies
Population
Confidence Intervals
Antibodies
Physicians
Self Report
Immunoglobulin A
Medical Records
Diarrhea
Interviews
Surveys and Questionnaires
transglutaminase 2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia : A Population-Based Case-Control Study. / Locke, G. Richard; Murray, Joseph A; Zinsmeister, Alan R.; Melton, L. Joseph; Talley, Nicholas J.

In: Mayo Clinic Proceedings, Vol. 79, No. 4, 2004, p. 476-482.

Research output: Contribution to journalArticle

Locke, G. Richard ; Murray, Joseph A ; Zinsmeister, Alan R. ; Melton, L. Joseph ; Talley, Nicholas J. / Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia : A Population-Based Case-Control Study. In: Mayo Clinic Proceedings. 2004 ; Vol. 79, No. 4. pp. 476-482.
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abstract = "Objective: To determine whether undiagnosed celiac disease is associated with irritable bowel syndrome (IBS) or dyspepsia in the community. Subjects and Methods: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota, residents aged 20 to 50 years. All respondents who reported symptoms of dyspepsia or IBS (cases) and all respondents without notable gastrointestinal symptoms (controls) were invited to participate (260 eligible subjects; 150 [58{\%}] were studied). Each respondent was examined by a physician, and the medical records of each were reviewed (3 subjects did not meet the criteria for dyspepsia or IBS at the time of the physician interview). Serum was obtained to measure antiendomysial antibodies and tissue transglutaminase (TTg) IgA antibodies using validated assays. Results: A total of 34 subjects had dyspepsia (20 had ulcerlike dyspepsia), 50 had IBS (19 had diarrhea-predominant IBS), and 15 met criteria for both dyspepsia and IBS; 78 were asymptomatic healthy controls. The overall prevalence of positive TTg serology was 4{\%} (95{\%} confidence interval [CI], 1.5{\%}-8.5{\%}). The number or subjects who were seropositive for TTg was 2 of 34 (5.9{\%}) with dyspepsia (95{\%} CI, 0.7{\%}-19.7{\%}), 2 of 50 (4.0{\%}) with IBS (95{\%} CI, 0.5{\%}-13.7{\%}), and 2 of 78 (2.6{\%}) of asymptomatic controls (95{\%} CI, 0.3{\%}-9.0{\%}) (P=.64 IBS vs controls; P=.58 dyspepsia vs controls). No subjects had positive antiendomysial antibodies. Conclusion: In this community, celiac disease did not explain the presence of either IBS or dyspepsia.",
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AB - Objective: To determine whether undiagnosed celiac disease is associated with irritable bowel syndrome (IBS) or dyspepsia in the community. Subjects and Methods: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota, residents aged 20 to 50 years. All respondents who reported symptoms of dyspepsia or IBS (cases) and all respondents without notable gastrointestinal symptoms (controls) were invited to participate (260 eligible subjects; 150 [58%] were studied). Each respondent was examined by a physician, and the medical records of each were reviewed (3 subjects did not meet the criteria for dyspepsia or IBS at the time of the physician interview). Serum was obtained to measure antiendomysial antibodies and tissue transglutaminase (TTg) IgA antibodies using validated assays. Results: A total of 34 subjects had dyspepsia (20 had ulcerlike dyspepsia), 50 had IBS (19 had diarrhea-predominant IBS), and 15 met criteria for both dyspepsia and IBS; 78 were asymptomatic healthy controls. The overall prevalence of positive TTg serology was 4% (95% confidence interval [CI], 1.5%-8.5%). The number or subjects who were seropositive for TTg was 2 of 34 (5.9%) with dyspepsia (95% CI, 0.7%-19.7%), 2 of 50 (4.0%) with IBS (95% CI, 0.5%-13.7%), and 2 of 78 (2.6%) of asymptomatic controls (95% CI, 0.3%-9.0%) (P=.64 IBS vs controls; P=.58 dyspepsia vs controls). No subjects had positive antiendomysial antibodies. Conclusion: In this community, celiac disease did not explain the presence of either IBS or dyspepsia.

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