Celiac Disease: Advances in Treatment via Gluten Modification

Samantha Stoven, Joseph A. Murray, Eric Marietta

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Celiac disease (CD) is an autoimmune enteropathy that occurs in genetically susceptible individuals carrying the prerequisite genetic markers HLA DQ2 or DQ8. These genetic markers are present in approximately 30% of the population, and the worldwide prevalence of CD is estimated to be approximately 1%-2%. Currently a gluten-free diet is the only treatment for CD, but novel therapies aimed at gluten modification are underway. This review will discuss gluten-based therapies including wheat alternatives and wheat selection, enzymatic alteration of wheat, oral enzyme supplements, and polymeric binders as exciting new therapies for treatment of CD.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalClinical Gastroenterology and Hepatology
Volume10
Issue number8
DOIs
StatePublished - Aug 2012

Keywords

  • Autoimmune
  • Celiac
  • Gluten
  • Therapies
  • Treatment

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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