Celiac disease: a clinical review

Badr Al-Bawardy; D. Chamil Codipilly; Alberto Rubio-Tapia; David H. Bruining; Stephanie L. Hansel; Joseph A. Murray

doi:10.1007/s00261-016-1034-y

Celiac disease: a clinical review

Badr Al-Bawardy, D. Chamil Codipilly, Alberto Rubio-Tapia, David H. Bruining, Stephanie L. Hansel, Joseph A. Murray

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy. Complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.

Original language	English (US)
Pages (from-to)	351-360
Number of pages	10
Journal	Abdominal Radiology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1007/s00261-016-1034-y
State	Published - Feb 1 2017

Keywords

Celiac disease
Enteropathy
Gluten free
Refractory
Sprue
imaging

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Gastroenterology
Urology

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10.1007/s00261-016-1034-y

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AU - Codipilly, D. Chamil

AU - Rubio-Tapia, Alberto

AU - Bruining, David H.

AU - Hansel, Stephanie L.

AU - Murray, Joseph A.

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AB - Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy. Complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.

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KW - Refractory

KW - Sprue

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Celiac disease: a clinical review

Abstract

Keywords

ASJC Scopus subject areas

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