Abstract
Celiac disease is characterized by an aberrant immune response to the storage proteins (gluten/gliadin) of wheat, rye, and barley, with wheat as the most immunogenic protein. The resultant inflammation in the proximal small intestine leads to the destruction of villi, resulting in malabsorption, and leading to a range of symptoms including diarrhea, steatorrhea, weight loss, and failure to thrive. Celiac disease develops in only a minority of genetically susceptible individuals. Initiation is frequently in childhood but can be at any age. Small bowel biopsy remains the gold standard for diagnosis. Treatment involves adherence to a strict gluten-free diet.
Original language | English (US) |
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Title of host publication | Encyclopedia of Human Nutrition |
Publisher | Elsevier Inc. |
Pages | 298-306 |
Number of pages | 9 |
Volume | 1-4 |
ISBN (Electronic) | 9780123848857 |
ISBN (Print) | 9780123750839 |
DOIs | |
State | Published - Jan 1 2012 |
Externally published | Yes |
Keywords
- Barley
- Celiac disease
- Endomysial antibody
- Gliadin
- Gliadin antibodies
- Gluten
- Gluten-free diet
- Malabsorption
- Rye
- Small bowel
- Tissue transglutaminase antibodies
- Villous atrophy
- Wheat
ASJC Scopus subject areas
- Medicine(all)