Celiac Disease

V. Nehra, E. V. Marietta, Joseph A Murray

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Celiac disease is characterized by an aberrant immune response to the storage proteins (gluten/gliadin) of wheat, rye, and barley, with wheat as the most immunogenic protein. The resultant inflammation in the proximal small intestine leads to the destruction of villi, resulting in malabsorption, and leading to a range of symptoms including diarrhea, steatorrhea, weight loss, and failure to thrive. Celiac disease develops in only a minority of genetically susceptible individuals. Initiation is frequently in childhood but can be at any age. Small bowel biopsy remains the gold standard for diagnosis. Treatment involves adherence to a strict gluten-free diet.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Human Nutrition
PublisherElsevier Inc.
Pages298-306
Number of pages9
Volume1-4
ISBN (Electronic)9780123848857
ISBN (Print)9780123750839
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Keywords

  • Barley
  • Celiac disease
  • Endomysial antibody
  • Gliadin
  • Gliadin antibodies
  • Gluten
  • Gluten-free diet
  • Malabsorption
  • Rye
  • Small bowel
  • Tissue transglutaminase antibodies
  • Villous atrophy
  • Wheat

ASJC Scopus subject areas

  • Medicine(all)

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