Celiac Crisis Is a Rare but Serious Complication of Celiac Disease in Adults

Shailaja Jamma, Alberto Rubio-Tapia, Ciaran P. Kelly, Joseph A Murray, Robert Najarian, Sunil Sheth, Detlef Schuppan, Melinda Dennis, Daniel A. Leffler

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background & Aims: Celiac crisis is a life-threatening syndrome in which patients with celiac disease have profuse diarrhea and severe metabolic disturbances. Celiac crisis is rare among adults and not well documented. To improve awareness of this condition and to facilitate diagnosis, we reviewed cases of celiac crisis to identify presenting features, formulate diagnostic criteria, and develop treatment strategies. Methods: Cases of biopsy-proven celiac disease were reviewed. Celiac crisis was defined as acute onset or rapid progression of gastrointestinal symptoms that could be attributed to celiac disease and required hospitalization and/or parenteral nutrition, along with signs or symptoms of dehydration or malnutrition. Results: Twelve patients met preset criteria for celiac crisis; 11 developed celiac crisis before they were diagnosed with celiac disease. Eleven patients had increased titres of transglutaminase antibodies and 1 had immunoglobulin A deficiency. Results of biopsy analyses of duodenum samples from all patients were consistent with a Marsh 3 score (33% with total villous atrophy). Patients presented with severe dehydration, renal dysfunction, and electrolyte disturbances. All patients required hospitalization and intravenous fluids, 6 required corticosteroids, and 5 required parenteral nutrition. All patients eventually had a full response to a gluten-free diet. Conclusions: Celiac crisis has a high morbidity and, although rarely described, occurs in adults and often has a clear precipitating factor. Patients who present with severe unexplained diarrhea and malabsorption should be tested for celiac disease; treatment with systemic steroids or oral budesonide should be considered. Nutritional support often is required in the short term but most patients ultimately respond to gluten avoidance.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalClinical Gastroenterology and Hepatology
Volume8
Issue number7
DOIs
StatePublished - Jul 2010

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Celiac Disease
Abdomen
Parenteral Nutrition
Dehydration
Diarrhea
Hospitalization
Biopsy
Gluten-Free Diet
Precipitating Factors
Budesonide
Nutritional Support
Glutens
Wetlands
Duodenum
Malnutrition
Immunoglobulin A
Electrolytes
Signs and Symptoms
Atrophy
Adrenal Cortex Hormones

Keywords

  • Enteropathy
  • Steroids
  • Tissue Transglutaminase
  • Treatment

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Celiac Crisis Is a Rare but Serious Complication of Celiac Disease in Adults. / Jamma, Shailaja; Rubio-Tapia, Alberto; Kelly, Ciaran P.; Murray, Joseph A; Najarian, Robert; Sheth, Sunil; Schuppan, Detlef; Dennis, Melinda; Leffler, Daniel A.

In: Clinical Gastroenterology and Hepatology, Vol. 8, No. 7, 07.2010, p. 587-590.

Research output: Contribution to journalArticle

Jamma, S, Rubio-Tapia, A, Kelly, CP, Murray, JA, Najarian, R, Sheth, S, Schuppan, D, Dennis, M & Leffler, DA 2010, 'Celiac Crisis Is a Rare but Serious Complication of Celiac Disease in Adults', Clinical Gastroenterology and Hepatology, vol. 8, no. 7, pp. 587-590. https://doi.org/10.1016/j.cgh.2010.04.009
Jamma, Shailaja ; Rubio-Tapia, Alberto ; Kelly, Ciaran P. ; Murray, Joseph A ; Najarian, Robert ; Sheth, Sunil ; Schuppan, Detlef ; Dennis, Melinda ; Leffler, Daniel A. / Celiac Crisis Is a Rare but Serious Complication of Celiac Disease in Adults. In: Clinical Gastroenterology and Hepatology. 2010 ; Vol. 8, No. 7. pp. 587-590.
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