Ceftazidime pulmonary epithelial lining fluid concentrations during continuous and intermittent infusion in swine

Scott D. Hanes, G. Christopher Wood, Timothy D. Mandrell, Naomi M Gades

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pharmacokinetics and pharmacodynamics (T>MIC) of ceftazidime in the plasma and pulmonary epithelial lining fluid (ELF) were compared following intermittent (IC) and continuous ceftazidime (CC) infusion (60 mg/kg/d) in nine crossbred male intact pigs. The ceftazidime plasma half-life, volume of distribution, clearance, and area under the plasma concentration-time curve were similar between the IC and CC regimens. Ceftazidime area under the ELF concentration-time curve were 29.6% and 23.4% of the area under the plasma concentration-time curve for the IC and CC regimens, respectively. The ceftazidime half-life in the ELF was approximately two-fold longer compared to the plasma half-life. This suggests that the penetration of ceftazidime into the ELF is membrane-limited and may not display compartmental pharmacokinetic characteristics. Using T>MIC as a surrogate marker of efficacy, ceftazidime's limited ELF penetration may hinder pharmacodynamic optimization against less susceptible gram-negative bacteria causing pneumonia.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalJournal of Infectious Disease Pharmacotherapy
Volume4
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Ceftazidime
Swine
Lung
Half-Life
Pharmacokinetics
Gram-Negative Bacteria
Pneumonia
Biomarkers
Membranes

Keywords

  • Administrations and dosage
  • Alveolar lining fluid
  • Analysis
  • Bronchoalveolar lavage
  • Ceftazidime
  • Pharmacokinetics
  • Swine

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)

Cite this

Ceftazidime pulmonary epithelial lining fluid concentrations during continuous and intermittent infusion in swine. / Hanes, Scott D.; Wood, G. Christopher; Mandrell, Timothy D.; Gades, Naomi M.

In: Journal of Infectious Disease Pharmacotherapy, Vol. 4, No. 4, 2001, p. 29-41.

Research output: Contribution to journalArticle

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