Ceftazidime pulmonary epithelial lining fluid concentrations during continuous and intermittent infusion in swine

Scott D. Hanes, G. Christopher Wood, Timothy D. Mandrell, Naomi M. Gades

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The pharmacokinetics and pharmacodynamics (T>MIC) of ceftazidime in the plasma and pulmonary epithelial lining fluid (ELF) were compared following intermittent (IC) and continuous ceftazidime (CC) infusion (60 mg/kg/d) in nine crossbred male intact pigs. The ceftazidime plasma half-life, volume of distribution, clearance, and area under the plasma concentration-time curve were similar between the IC and CC regimens. Ceftazidime area under the ELF concentration-time curve were 29.6% and 23.4% of the area under the plasma concentration-time curve for the IC and CC regimens, respectively. The ceftazidime half-life in the ELF was approximately two-fold longer compared to the plasma half-life. This suggests that the penetration of ceftazidime into the ELF is membrane-limited and may not display compartmental pharmacokinetic characteristics. Using T>MIC as a surrogate marker of efficacy, ceftazidime's limited ELF penetration may hinder pharmacodynamic optimization against less susceptible gram-negative bacteria causing pneumonia.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalJournal of Infectious Disease Pharmacotherapy
Volume4
Issue number4
DOIs
StatePublished - Dec 1 2001

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Keywords

  • Administrations and dosage
  • Alveolar lining fluid
  • Analysis
  • Bronchoalveolar lavage
  • Ceftazidime
  • Pharmacokinetics
  • Swine

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)

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