Ceftazidime nephrotoxicity in rats

F. C. Luft, Daniel W Visscher, D. M. Nierste, D. K. Blase, N. A. Walker, G. R. Aronoff

Research output: Contribution to journalArticle

2 Scopus citations


The nephrotoxicity of ceftazidime compared with that of cefazolin or cephaloridine and the capacity of ceftazidime to enhance the nephrotoxicity of tobramycin were evaluated in rats. Only cephaloridine and tobramycin given alone altered creatinine clearance or caused significant histological injury. Our data suggest that ceftazidime is no more nephrotoxic than cefazolin and does not enhance the nephrotoxicity of tobramycin.

Original languageEnglish (US)
Pages (from-to)513-514
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Issue number4
StatePublished - 1984
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Luft, F. C., Visscher, D. W., Nierste, D. M., Blase, D. K., Walker, N. A., & Aronoff, G. R. (1984). Ceftazidime nephrotoxicity in rats. Antimicrobial Agents and Chemotherapy, 25(4), 513-514.