Ceftazidime nephrotoxicity in rats

F. C. Luft, D. W. Visscher, D. M. Nierste, D. K. Blase, N. A. Walker, G. R. Aronoff

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The nephrotoxicity of ceftazidime compared with that of cefazolin or cephaloridine and the capacity of ceftazidime to enhance the nephrotoxicity of tobramycin were evaluated in rats. Only cephaloridine and tobramycin given alone altered creatinine clearance or caused significant histological injury. Our data suggest that ceftazidime is no more nephrotoxic than cefazolin and does not enhance the nephrotoxicity of tobramycin.

Original languageEnglish (US)
Pages (from-to)513-514
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume25
Issue number4
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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