Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

Larry M. Karnitz, Sara J. Felts

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Although massive genome sequencing efforts have identified the protein kinases encoded by several eukaryotic genomes and proteomic analyses have begun to determine the kinases expressed in a cell, there is still much to learn about the additional cellular events that shape eukaryotic kinomes. Large-scale analyses in Saccharomyces cerevisiae have indicated that a relatively small subset of kinases requires chaperoning by heat shock protein 90 (Hsp90). However, new evidence suggests that most kinases do require chaperoning and, furthermore, that Cdc37, a chaperone that has Hsp90-dependent and -independent functions, serves as the chaperone for a large portion of the yeast kinome.

Original languageEnglish (US)
Pages (from-to)pe22
JournalScience's STKE : signal transduction knowledge environment
Volume2007
Issue number385
DOIs
StatePublished - May 26 2007

ASJC Scopus subject areas

  • Medicine(all)

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