CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential

Tomoyuki Shimazu, Ryuji Iida, Qingzhao Zhang, Robert S. Welner, Kay L. Medina, José Alberola-lla, Paul W. Kincade

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A unique subset of CD86 - HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86 - CD150 + CD48 - HSCs from normal adult mice are particularly poor at restoring the adaptive immune system. Levels of the marker are high on all progenitors with lymphopoietic potential, and progressive loss helps to establish relations between progenitors corresponding to myeloid and erythroid lineages. CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.

Original languageEnglish (US)
Pages (from-to)4889-4897
Number of pages9
JournalBlood
Volume119
Issue number21
DOIs
StatePublished - May 24 2012

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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