CD8-positive primary cutaneous anaplastic large T-Cell Lymphoma (PCALCL): Case report and review of this unusual variant of PCALCL

Jose A. Plaza, Pablo Ortega, James Lynott, Michael Mullane, Steve Kroft, Horatiu Olteanu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Primary cutaneous anaplastic large T-cell lymphoma (PCALCL) is a well-defined CD30-positive lymphoproliferative disorder with relatively good prognosis and response to treatment. We describe a case of PCALCL expressing CD8. The patient is a 57-year-old man that clinically presented with an ulcerated nodule in his left middle finger. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. The large cohesive atypical cells were admixed with a reactive infiltrate composed of neutrophils, eosinophils, and small lymphocytes. Immunohistochemical studies showed the tumor cells to be strongly positive for CD8, CD30, and TIA-1, focally positive for CD3, and negative for CD4, CD20, CD56, Anaplastic Lymphoma Kinase (ALK-1), and HSV. Epstein-Barr virus by in situ hybridization was negative. The diagnosis of a CD8 (+) PCALCL was confirmed. There is limited precedent literature regarding CD8-positive PCALCL and this case falls within the clinical and histopathologic spectrum of CD30+ lymphoproliferative disorders. CD8/CD30 coexpression is rare in PCALCL and may have important clinical and prognostic implications. To the best of our knowledge there are only 4 previously reported cases describing similar findings.

Original languageEnglish (US)
Pages (from-to)489-491
Number of pages3
JournalAmerican Journal of Dermatopathology
Volume32
Issue number5
DOIs
StatePublished - Jul 1 2010

Keywords

  • primary cutaneous anaplastic large T-cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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