CD58 expression decreases as nonmalignant B cells mature in bone marrow and is frequently overexpressed in adult and pediatric precursor B-cell acute lymphoblastic leukemia

Ronald V. Lee, Raul C. Braylan, Lisa M. Rimsza

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We used flow cytometry to determine the CD58 expression on nonmalignant B cells at different stages of maturation in the bone marrow and compared it with that of blasts in adult and pediatric precursor B-cell acute lymphoblastic leukemia (B-ALL). The mean fluorescence intensity (MFI) of CD58 expression decreased significantly as nonmalignant B cells differentiated in the bone marrow from an early to a mature stage. Few nonneoplastic B cells at a mid or mature stage of development expressed CD58 MFI values comparable to those seen in leukemic cases. Early-stage nonneoplastic B-cell precursors expressed relatively higher CD58 levels, which frequently overlapped with the variable level of CD58 expression observed among leukemic blasts. As a group, however, the malignant precursor B-ALL cells showed significantly higher expression of CD58 than nonmalignant B-cell populations at any maturational stage. These findings support the potential usefulness of CD58 expression in the diagnosis and monitoring of precursor B-ALL, but only when blasts express high levels of CD58.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalAmerican journal of clinical pathology
Volume123
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Acute lymphoblastic leukemia
  • CD2 ligand
  • CD58
  • Hematogones
  • LFA-3
  • Precursor B cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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