CD46 in meningococcal disease

Linda Johansson, Anne Rytkönen, Peter Bergman, Barbara Albiger, Helena Källström, Tomas Hökfelt, Birgitta Agerberth, Roberto Cattaneo, Ann Beth Jonsson

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
JournalScience
Volume301
Issue number5631
DOIs
StatePublished - Jul 18 2003

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'CD46 in meningococcal disease'. Together they form a unique fingerprint.

Cite this