CD44 cell adhesion molecules

Steven Goodison, V. Urquidi, D. Tarin

Research output: Contribution to journalReview article

434 Citations (Scopus)

Abstract

The CD44 proteins form a ubiquitously expressed family of cell surface adhesion molecules involved in cell-cell and cell-matrix interactions. The multiple protein isoforms are encoded by a single gene by alternative splicing and are further modified by a range of post-translational modifications. CD44 proteins are single chain molecules comprising an N- terminal extracellular domain, a membrane proximal region, a transmembrane domain, and a cytoplasmic tail. The CD44 gene has only been detected in higher organisms and the amino acid sequence of most of the molecule is highly conserved between mammalian species. The principal ligand of CD44 is hyaluronic acid, an integral component of the extracellular matrix. Other CD44 ligands include osteopontin, serglycin, collagens, fibronectin, and laminin. The major physiological role of CD44 is to maintain organ and tissue structure via cell-cell and cell-matrix adhesion, but certain variant isoforms can also mediate lymphocyte activation and homing, and the presentation of chemical factors and hormones. Increased interest has been directed at the characterisation of this molecule since it was observed that expression of multiple CD44 isoforms is greatly upregulated in neoplasia. CD44, particularly its variants, may be useful as a diagnostic or prognostic marker of malignancy and, in at least some human cancers, it may be a potential target for cancer therapy. This review describes the structure of the CD44 gene and discusses some of its roles in physiological and pathological processes.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalJournal of Clinical Pathology - Molecular Pathology
Volume52
Issue number4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Cell Adhesion Molecules
Protein Isoforms
Neoplasms
Cell-Matrix Junctions
Physiological Phenomena
Genes
Ligands
Osteopontin
Alternative Splicing
Laminin
Pathologic Processes
Hyaluronic Acid
Post Translational Protein Processing
Lymphocyte Activation
Fibronectins
Cell Communication
Extracellular Matrix
Tail
Amino Acid Sequence
Proteins

Keywords

  • Alternative splicing
  • CD44 structure
  • Hyaluronic acid
  • Neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

CD44 cell adhesion molecules. / Goodison, Steven; Urquidi, V.; Tarin, D.

In: Journal of Clinical Pathology - Molecular Pathology, Vol. 52, No. 4, 01.01.1999, p. 189-196.

Research output: Contribution to journalReview article

Goodison, Steven ; Urquidi, V. ; Tarin, D. / CD44 cell adhesion molecules. In: Journal of Clinical Pathology - Molecular Pathology. 1999 ; Vol. 52, No. 4. pp. 189-196.
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