CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Xiaoqi Lin; Xiaoxing Ma; Moses Rodriguez; Raymond P. Roos

doi:10.1093/intimm/dxh125

CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Xiaoqi Lin, Xiaoxing Ma, Moses Rodriguez, Raymond P. Roos

Neurology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains. are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

Original language	English (US)
Pages (from-to)	1237-1240
Number of pages	4
Journal	International Immunology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1093/intimm/dxh125
State	Published - Sep 2004

Keywords

Anti-virus immunity
Immune-mediated demyelination

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1093/intimm/dxh125

Cite this

@article{8a9fbaad37694d3683d338df6588c918,

title = "CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice",

abstract = "DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains. are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.",

keywords = "Anti-virus immunity, Immune-mediated demyelination",

author = "Xiaoqi Lin and Xiaoxing Ma and Moses Rodriguez and Roos, {Raymond P.}",

note = "Funding Information: This work was partly supported by grants from the NIH (5RO1 NS37958-05, RO1-NS32129 and P01-NS38468) and the National Multiple Sclerosis Society (RG3160-A-9).",

year = "2004",

month = sep,

doi = "10.1093/intimm/dxh125",

language = "English (US)",

volume = "16",

pages = "1237--1240",

journal = "International Immunology",

issn = "0953-8178",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

AU - Lin, Xiaoqi

AU - Ma, Xiaoxing

AU - Rodriguez, Moses

AU - Roos, Raymond P.

N1 - Funding Information: This work was partly supported by grants from the NIH (5RO1 NS37958-05, RO1-NS32129 and P01-NS38468) and the National Multiple Sclerosis Society (RG3160-A-9).

PY - 2004/9

Y1 - 2004/9

N2 - DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains. are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

AB - DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains. are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

KW - Anti-virus immunity

KW - Immune-mediated demyelination

UR - http://www.scopus.com/inward/record.url?scp=4544310691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544310691&partnerID=8YFLogxK

U2 - 10.1093/intimm/dxh125

DO - 10.1093/intimm/dxh125

M3 - Article

C2 - 15262897

AN - SCOPUS:4544310691

SN - 0953-8178

VL - 16

SP - 1237

EP - 1240

JO - International Immunology

JF - International Immunology

IS - 9

ER -

CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this