CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Xiaoqi Lin, Xiaoxing Ma, Moses Rodriguez, Raymond P. Roos

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains. are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

Original languageEnglish (US)
Pages (from-to)1237-1240
Number of pages4
JournalInternational Immunology
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2004

Keywords

  • Anti-virus immunity
  • Immune-mediated demyelination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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