@article{8c26f607bcd24931b8732838a983518f,
title = "CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism",
abstract = "Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in age-related metabolic decline. To date, the mechanism responsible for the age-related reduction in NAD has not been elucidated. Here we demonstrate that expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity. We also identified CD38 as the main enzyme involved in the degradation of the NAD precursor nicotinamide mononucleotide (NMN) in vivo, indicating that CD38 has a key role in the modulation of NAD-replacement therapy for aging and metabolic diseases.",
keywords = "CD38, NAD, aging, glucose intolerance, mitochondrial function",
author = "Juliana Camacho-Pereira and Tarrag{\'o}, {Mariana G.} and Chini, {Claudia C.S.} and Veronica Nin and Carlos Escande and Warner, {Gina M.} and Puranik, {Amrutesh S.} and Schoon, {Renee A.} and Reid, {Joel M.} and Antonio Galina and Chini, {Eduardo N.}",
note = "Funding Information: This work was supported in part by grants from the American Federation for Aging Research, the Mayo Foundation, the Strickland Career Development Award, NIH grants from the National Institute of Aging (NIA, grant AG-26094) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, grant DK-084055), Mayo-UOFM Decade of Discovery Grant 63-01, and Minnesota Obesity Council Grant DK-50456-15. J.C.-P. is supported by grants from the Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico/Brazil(CNPQ) and Funda{\c c}{\~a}o de Amparo {\'e} Pesquisa do Rio de Janeiro/Brazil (FAPERJ). E.N.C. holds patents on the use of CD38 inhibitors. ",
year = "2016",
month = jun,
day = "14",
doi = "10.1016/j.cmet.2016.05.006",
language = "English (US)",
volume = "23",
pages = "1127--1139",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}