CD30 expression in monomorphic posttransplant lymphoproliferative disorder, diffuse large b-cell lymphoma correlates with greater regulatory t-cell infiltration

Christopher Hartley, James W. Vaughan, Jason Jarzembowski, Steven H. Kroft, Paul Hosking, Alexandra M. Harrington, Horatiu Olteanu

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objectives: CD30 is a protein thought to promote cell proliferation/survival and downregulate the immune response. Twenty percent to 40% of de novo diffuse large B-cell lymphomas (DLBCLs) express CD30, and some patients have been treated with the anti-CD30 agent brentuximab. In the solid organ transplant setting, allograft regulatory T cells (Tregs) have been shown to be modulated via CD30 signaling. Methods: Posttransplant lymphoproliferative disorders (PTLDs) constitute a heterogeneous group of lymphomas, and since CD30 expression has been rarely formally assessed in PTLDs, we analyzed a cohort of PTLDs. Results: We found that 26 (79%) of 33 PTLDs were CD30+. Of these, 17 (77%) of 22 DLBCL monomorphic PTLDs were CD30+ compared with 56 (38%) of 148 de novo DLBCLs (P = .009). The median FoxP3+ Treg count was higher in CD30+ than in CD30- PTLDs, 3.0 vs 0 (P = .012). Conclusions: These findings suggest a pathophysiologic link between CD30 activity and Tregs and may indicate differential expression of CD30 in B-cell lymphomas arising in the setting of immune dysregulation.

Original languageEnglish (US)
Pages (from-to)485-493
Number of pages9
JournalAmerican journal of clinical pathology
Volume148
Issue number6
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Keywords

  • CD30
  • Diffuse large B-cell lymphoma
  • FoxP3
  • Posttransplant lymphoproliferative disorder
  • Tregs

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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