TY - JOUR
T1 - CD28- T cells
T2 - their role in the age-associated decline of immune function
AU - Weng, Nan ping
AU - Akbar, Arne N.
AU - Goronzy, Jorg
N1 - Funding Information:
N-P.W. was supported by the Intramural Research Programs of the National Institute on Aging, National Institutes of Health (NIH). A.N.A. is supported by the British Biotechnological and Biological Sciences Research Council. J.G. is supported by RO1-AR41974, RO1-AG15043 and U19-AI57266.
PY - 2009/7
Y1 - 2009/7
N2 - The accumulation of CD28- T cells, particularly within the CD8 subset, is one of the most prominent changes during T-cell homeostasis and function associated with aging in humans. CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T-cell activation, proliferation and survival of T cells. CD28- T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28- T cells in comparison to their CD28+ counterparts and corroborate their functional differences. Here we review recent advances in our understanding of CD28- T cells and their role in the age-associated decline of immune function.
AB - The accumulation of CD28- T cells, particularly within the CD8 subset, is one of the most prominent changes during T-cell homeostasis and function associated with aging in humans. CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T-cell activation, proliferation and survival of T cells. CD28- T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28- T cells in comparison to their CD28+ counterparts and corroborate their functional differences. Here we review recent advances in our understanding of CD28- T cells and their role in the age-associated decline of immune function.
UR - http://www.scopus.com/inward/record.url?scp=67649407892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649407892&partnerID=8YFLogxK
U2 - 10.1016/j.it.2009.03.013
DO - 10.1016/j.it.2009.03.013
M3 - Review article
C2 - 19540809
AN - SCOPUS:67649407892
SN - 1471-4906
VL - 30
SP - 306
EP - 312
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -