Abstract
New therapeutic modalities for B-cell non-Hodgkin's lymphomas (B-NHL) are needed, especially for relapsing and aggressive subtypes. Toward this end, we previously generated a fully CD20-targeted and armed measles virus, and tested its efficacy in a xenograft model of mantle cell lymphoma (MCL). Here, we quantify its spread in peripheral blood mononuclear cells and/or tissue of patients with different histological subtypes of B-NHL, including splenic marginal zone lymphoma (SMZL). CD20-targeted MV efficiently infects lymphoma cells from SMZL and MCL while sparing most cells in the CD20-negative population, in contrast to the parental vaccine-lineage MV, which infects CD20-positive and CD20-negative cells equally. Rituximab therapy (4-8 months before relapse) did not interfere with the infectivity and specificity of MVgreenHblind antiCD20 in patient lymphoma samples. Thus, CD20-targeted oncolytic virotherapy is likely to be effective after previous antiCD20 therapy.
Original language | English (US) |
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Pages (from-to) | 313-317 |
Number of pages | 5 |
Journal | Gene Therapy |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2011 |
Keywords
- CD-20
- lymphoma
- oncolytic virotherapy
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Genetics