TY - JOUR
T1 - Causes and palliation of transfusion-associated vaginal bleeding in patients with metastatic cancer
AU - Jackson, Amie E.
AU - Stephens, Elisabeth K.
AU - Jatoi, Aminah
PY - 2014/1
Y1 - 2014/1
N2 - Purpose: The current study was undertaken (1) to capture a clinically relevant, systematically collected series of patients with metastatic cancer and transfusion-associated vaginal bleeding and (2) to provide insight into how best to palliate this bleeding. Methods/Results: As part of a single-institution review, 46 patients with metastatic cancer and transfusion-associated vaginal bleeding were identified. In a minority, 14 (30%), the cancer itself was directly responsible for the bleeding, and under these circumstances, gynecological cancerwas themost frequent cause. In 13 patients (28%),more than 1 palliative intervention was attempted. Of all the interventions, a hysterectomy was performed most frequently and was successful in 11 patients. The use of ablation or embolization procedures was rarely tried but successful in 4 patients. However, 2 patients died of vaginal bleeding, despite multiple palliative procedures to control bleeding, including tumor embolization in one. Conclusions: Transfusion-associated vaginal bleeding in patients with etastatic cancer can arise from nonmalignant causes and often assumes an uneventful course but can, at times, be serious and difficult to control.
AB - Purpose: The current study was undertaken (1) to capture a clinically relevant, systematically collected series of patients with metastatic cancer and transfusion-associated vaginal bleeding and (2) to provide insight into how best to palliate this bleeding. Methods/Results: As part of a single-institution review, 46 patients with metastatic cancer and transfusion-associated vaginal bleeding were identified. In a minority, 14 (30%), the cancer itself was directly responsible for the bleeding, and under these circumstances, gynecological cancerwas themost frequent cause. In 13 patients (28%),more than 1 palliative intervention was attempted. Of all the interventions, a hysterectomy was performed most frequently and was successful in 11 patients. The use of ablation or embolization procedures was rarely tried but successful in 4 patients. However, 2 patients died of vaginal bleeding, despite multiple palliative procedures to control bleeding, including tumor embolization in one. Conclusions: Transfusion-associated vaginal bleeding in patients with etastatic cancer can arise from nonmalignant causes and often assumes an uneventful course but can, at times, be serious and difficult to control.
KW - Anemia
KW - Hemorrhage
KW - Palliation
KW - Uterine bleeding
KW - Vaginal bleeding
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U2 - 10.1097/IGC.0000000000000017
DO - 10.1097/IGC.0000000000000017
M3 - Article
C2 - 24270998
AN - SCOPUS:84893712494
SN - 1048-891X
VL - 24
SP - 172
EP - 175
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 1
ER -