Catheter salvage after catheter-related bloodstream infection during home parenteral nutrition

Jithinraj Edakkanambeth Varayil, Jennifer A. Whitaker, Akiko Okano, Jennifer J. Carnell, Jacob B. Davidson, Mark J. Enzler, Darlene G. Kelly, Manpreet S. Mundi, Ryan T Hurt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Catheter-related bloodstream infection (CRBSI) is a common complication in patients receiving home parenteral nutrition (HPN). Data regarding catheter salvage after a CRBSI episode are limited. We aimed to determine the incidence of CRBSI and rates of catheter salvage in adult patients receiving HPN. Materials and Methods: We retrospectively searched our prospectively maintained HPN database for the records of all adult patients receiving HPN from January 1, 1990, to December 31, 2013, at our tertiary referral center. Data abstracted from the medical records included demographics, diseases, treatments, and outcomes. The incidence of CRBSI and rates of catheter salvage were determined. Results: Of 1040 patients identified, 620 (59.6%) were men. The median total duration on HPN was 124.5 days (interquartile range, 49.0-345.5 days). Mean (SD) age at HPN initiation was 53.3 (15.3) years. During the study period, 465 CRBSIs developed in 187 patients (18%). The rate of CRBSI was 0.64/1000 catheter days. Overall, 70% of catheters were salvaged (retained despite CRBSI) during the study period: 78% of infections with coagulase-negative staphylococci, 87% with methicillin-sensitive Staphylococcus aureus, and 27% with methicillin-resistant S aureus. The percentage of catheters salvaged was 63% from 1990 to 1994, 63% from 1995 to 1999, 61% from 2000 to 2004, 72% from 2005 to 2009, and 76% from 2010 to 2013. Conclusion: Catheter salvage is possible after a CRBSI episode. Since most episodes of CRBSI are caused by skin commensals, effective treatment without removal of the central venous catheter is possible in most cases.

Original languageEnglish (US)
Pages (from-to)481-488
Number of pages8
JournalJournal of Parenteral and Enteral Nutrition
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Home Parenteral Nutrition
Catheter-Related Infections
Catheters
Methicillin Resistance
Methicillin
Central Venous Catheters
Coagulase
Incidence
Staphylococcus
Tertiary Care Centers
Medical Records
Staphylococcus aureus
Demography
Databases
Skin

Keywords

  • catheter salvage
  • catheter-related bloodstream infection
  • coagulase-negative staphylococci
  • home parenteral nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Edakkanambeth Varayil, J., Whitaker, J. A., Okano, A., Carnell, J. J., Davidson, J. B., Enzler, M. J., ... Hurt, R. T. (2017). Catheter salvage after catheter-related bloodstream infection during home parenteral nutrition. Journal of Parenteral and Enteral Nutrition, 41(3), 481-488. https://doi.org/10.1177/0148607115587018

Catheter salvage after catheter-related bloodstream infection during home parenteral nutrition. / Edakkanambeth Varayil, Jithinraj; Whitaker, Jennifer A.; Okano, Akiko; Carnell, Jennifer J.; Davidson, Jacob B.; Enzler, Mark J.; Kelly, Darlene G.; Mundi, Manpreet S.; Hurt, Ryan T.

In: Journal of Parenteral and Enteral Nutrition, Vol. 41, No. 3, 01.03.2017, p. 481-488.

Research output: Contribution to journalArticle

Edakkanambeth Varayil, J, Whitaker, JA, Okano, A, Carnell, JJ, Davidson, JB, Enzler, MJ, Kelly, DG, Mundi, MS & Hurt, RT 2017, 'Catheter salvage after catheter-related bloodstream infection during home parenteral nutrition', Journal of Parenteral and Enteral Nutrition, vol. 41, no. 3, pp. 481-488. https://doi.org/10.1177/0148607115587018
Edakkanambeth Varayil J, Whitaker JA, Okano A, Carnell JJ, Davidson JB, Enzler MJ et al. Catheter salvage after catheter-related bloodstream infection during home parenteral nutrition. Journal of Parenteral and Enteral Nutrition. 2017 Mar 1;41(3):481-488. https://doi.org/10.1177/0148607115587018
Edakkanambeth Varayil, Jithinraj ; Whitaker, Jennifer A. ; Okano, Akiko ; Carnell, Jennifer J. ; Davidson, Jacob B. ; Enzler, Mark J. ; Kelly, Darlene G. ; Mundi, Manpreet S. ; Hurt, Ryan T. / Catheter salvage after catheter-related bloodstream infection during home parenteral nutrition. In: Journal of Parenteral and Enteral Nutrition. 2017 ; Vol. 41, No. 3. pp. 481-488.
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abstract = "Background: Catheter-related bloodstream infection (CRBSI) is a common complication in patients receiving home parenteral nutrition (HPN). Data regarding catheter salvage after a CRBSI episode are limited. We aimed to determine the incidence of CRBSI and rates of catheter salvage in adult patients receiving HPN. Materials and Methods: We retrospectively searched our prospectively maintained HPN database for the records of all adult patients receiving HPN from January 1, 1990, to December 31, 2013, at our tertiary referral center. Data abstracted from the medical records included demographics, diseases, treatments, and outcomes. The incidence of CRBSI and rates of catheter salvage were determined. Results: Of 1040 patients identified, 620 (59.6{\%}) were men. The median total duration on HPN was 124.5 days (interquartile range, 49.0-345.5 days). Mean (SD) age at HPN initiation was 53.3 (15.3) years. During the study period, 465 CRBSIs developed in 187 patients (18{\%}). The rate of CRBSI was 0.64/1000 catheter days. Overall, 70{\%} of catheters were salvaged (retained despite CRBSI) during the study period: 78{\%} of infections with coagulase-negative staphylococci, 87{\%} with methicillin-sensitive Staphylococcus aureus, and 27{\%} with methicillin-resistant S aureus. The percentage of catheters salvaged was 63{\%} from 1990 to 1994, 63{\%} from 1995 to 1999, 61{\%} from 2000 to 2004, 72{\%} from 2005 to 2009, and 76{\%} from 2010 to 2013. Conclusion: Catheter salvage is possible after a CRBSI episode. Since most episodes of CRBSI are caused by skin commensals, effective treatment without removal of the central venous catheter is possible in most cases.",
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AU - Davidson, Jacob B.

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