Catheter based treatments for fibrosing mediastinitis

Erin A. Fender, R. Jay Widmer, Erica M. Knavel Koepsel, John P. Welby, Ryan Kern, Tobias Peikert, Haraldur Bjarnason, David R. Holmes

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Fibrosing mediastinitis is a rare, often debilitating and potentially lethal disease characterized by an exuberant fibroinflammatory response within the mediastinum. Patients typically present with insidious symptoms related to compression of adjacent structures including the esophagus, heart, airways, and cardiac vessels. Fibrosing mediastinitis is most often triggered by Histoplasmosis infection; however, antifungal and anti-inflammatory therapies are largely ineffective. While structural interventions aimed at alleviating obstruction can provide significant palliation, surgical interventions are challenging with high mortality and clinical experience with percutaneous interventions is limited. Here, we will review the presentation, natural history, and treatment of fibrosing mediastinitis, placing particular emphasis on catheter-based therapies.

Original languageEnglish (US)
Pages (from-to)878-885
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume94
Issue number6
DOIs
StatePublished - Nov 15 2019

Keywords

  • histoplasmosis
  • pulmonary artery stenosis
  • pulmonary artery stent
  • pulmonary vein stenosis
  • pulmonary vein stent

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Fender, E. A., Widmer, R. J., Knavel Koepsel, E. M., Welby, J. P., Kern, R., Peikert, T., Bjarnason, H., & Holmes, D. R. (2019). Catheter based treatments for fibrosing mediastinitis. Catheterization and Cardiovascular Interventions, 94(6), 878-885. https://doi.org/10.1002/ccd.28152