Catheter ablation for atrial fibrillation in patients with obesity

Yong-Mei Cha, Paul Andrew Friedman, Samuel J Asirvatham, Win Kuang Shen, Thomas M. Munger, Robert F. Rea, Peter A. Brady, Arshad Jahangir, Kristi H. Monahan, David O. Hodge, Ryan A. Meverden, Bernard J. Gersh, Stephen C. Hammill, Douglas L Packer

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated atrial fibrillation in obese patients. Methods and Results Five hundred twenty-three consecutive patients with symptomatic, medication-refractory atrial fibrillation underwent catheter ablation. Patients were grouped by body mass index (lean, <25 kg/m2; overweight, 25 to 29.9 kg/m2; obese, <30 kg/m2). Outcome and quality of life were measured with a general health survey (Medical Outcomes Study 36-item Short-Form General Health Survey [SF-36]); patients were assessed before ablation and at 3 and 12 months after the procedure. Two hundred twenty-eight study patients (44%) were overweight, and 201 (38%) were obese. Twelve months after curative ablation, 72% of patients were free of atrial fibrillation without the use of antiarrhythmic agents; 84% were arrhythmia free when those receiving medication were included. Atrial fibrillation was eliminated in 75%, 72%, and 70% of the lean, overweight, and obese patients, respectively, at 12 months (P>0.41, trend test). SF-36 scores were lower for patients with higher body mass index (P<0.05) at baseline. SF-36 scores improved in every functional domain for all body mass index groups after ablation. The mean SF-36 total physical score increased from 59±20 at baseline to 77±19 in 12 months (P<0.001). The total mental health score improved from 66±18 to 79±16 in 12 months (P <0.001). Conclusions Catheter ablation of atrial fibrillation was effective in obese patients. Coexistence of atrial fibrillation and obesity indicated lower SF-36 scores, but the improvement in quality of life was consistent across all body mass index categories. (Circulation. 2008;117:2583-2590.)

Original languageEnglish (US)
Pages (from-to)2583-2590
Number of pages8
JournalCirculation
Volume117
Issue number20
DOIs
StatePublished - May 20 2008

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Catheter Ablation
Atrial Fibrillation
Obesity
Body Mass Index
Mental Health
Quality of Life

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Obesity
  • Quality of life

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Catheter ablation for atrial fibrillation in patients with obesity. / Cha, Yong-Mei; Friedman, Paul Andrew; Asirvatham, Samuel J; Shen, Win Kuang; Munger, Thomas M.; Rea, Robert F.; Brady, Peter A.; Jahangir, Arshad; Monahan, Kristi H.; Hodge, David O.; Meverden, Ryan A.; Gersh, Bernard J.; Hammill, Stephen C.; Packer, Douglas L.

In: Circulation, Vol. 117, No. 20, 20.05.2008, p. 2583-2590.

Research output: Contribution to journalArticle

Cha, Y-M, Friedman, PA, Asirvatham, SJ, Shen, WK, Munger, TM, Rea, RF, Brady, PA, Jahangir, A, Monahan, KH, Hodge, DO, Meverden, RA, Gersh, BJ, Hammill, SC & Packer, DL 2008, 'Catheter ablation for atrial fibrillation in patients with obesity', Circulation, vol. 117, no. 20, pp. 2583-2590. https://doi.org/10.1161/CIRCULATIONAHA.107.716712
Cha, Yong-Mei ; Friedman, Paul Andrew ; Asirvatham, Samuel J ; Shen, Win Kuang ; Munger, Thomas M. ; Rea, Robert F. ; Brady, Peter A. ; Jahangir, Arshad ; Monahan, Kristi H. ; Hodge, David O. ; Meverden, Ryan A. ; Gersh, Bernard J. ; Hammill, Stephen C. ; Packer, Douglas L. / Catheter ablation for atrial fibrillation in patients with obesity. In: Circulation. 2008 ; Vol. 117, No. 20. pp. 2583-2590.
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abstract = "Background Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated atrial fibrillation in obese patients. Methods and Results Five hundred twenty-three consecutive patients with symptomatic, medication-refractory atrial fibrillation underwent catheter ablation. Patients were grouped by body mass index (lean, <25 kg/m2; overweight, 25 to 29.9 kg/m2; obese, <30 kg/m2). Outcome and quality of life were measured with a general health survey (Medical Outcomes Study 36-item Short-Form General Health Survey [SF-36]); patients were assessed before ablation and at 3 and 12 months after the procedure. Two hundred twenty-eight study patients (44{\%}) were overweight, and 201 (38{\%}) were obese. Twelve months after curative ablation, 72{\%} of patients were free of atrial fibrillation without the use of antiarrhythmic agents; 84{\%} were arrhythmia free when those receiving medication were included. Atrial fibrillation was eliminated in 75{\%}, 72{\%}, and 70{\%} of the lean, overweight, and obese patients, respectively, at 12 months (P>0.41, trend test). SF-36 scores were lower for patients with higher body mass index (P<0.05) at baseline. SF-36 scores improved in every functional domain for all body mass index groups after ablation. The mean SF-36 total physical score increased from 59±20 at baseline to 77±19 in 12 months (P<0.001). The total mental health score improved from 66±18 to 79±16 in 12 months (P <0.001). Conclusions Catheter ablation of atrial fibrillation was effective in obese patients. Coexistence of atrial fibrillation and obesity indicated lower SF-36 scores, but the improvement in quality of life was consistent across all body mass index categories. (Circulation. 2008;117:2583-2590.)",
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AU - Cha, Yong-Mei

AU - Friedman, Paul Andrew

AU - Asirvatham, Samuel J

AU - Shen, Win Kuang

AU - Munger, Thomas M.

AU - Rea, Robert F.

AU - Brady, Peter A.

AU - Jahangir, Arshad

AU - Monahan, Kristi H.

AU - Hodge, David O.

AU - Meverden, Ryan A.

AU - Gersh, Bernard J.

AU - Hammill, Stephen C.

AU - Packer, Douglas L

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N2 - Background Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated atrial fibrillation in obese patients. Methods and Results Five hundred twenty-three consecutive patients with symptomatic, medication-refractory atrial fibrillation underwent catheter ablation. Patients were grouped by body mass index (lean, <25 kg/m2; overweight, 25 to 29.9 kg/m2; obese, <30 kg/m2). Outcome and quality of life were measured with a general health survey (Medical Outcomes Study 36-item Short-Form General Health Survey [SF-36]); patients were assessed before ablation and at 3 and 12 months after the procedure. Two hundred twenty-eight study patients (44%) were overweight, and 201 (38%) were obese. Twelve months after curative ablation, 72% of patients were free of atrial fibrillation without the use of antiarrhythmic agents; 84% were arrhythmia free when those receiving medication were included. Atrial fibrillation was eliminated in 75%, 72%, and 70% of the lean, overweight, and obese patients, respectively, at 12 months (P>0.41, trend test). SF-36 scores were lower for patients with higher body mass index (P<0.05) at baseline. SF-36 scores improved in every functional domain for all body mass index groups after ablation. The mean SF-36 total physical score increased from 59±20 at baseline to 77±19 in 12 months (P<0.001). The total mental health score improved from 66±18 to 79±16 in 12 months (P <0.001). Conclusions Catheter ablation of atrial fibrillation was effective in obese patients. Coexistence of atrial fibrillation and obesity indicated lower SF-36 scores, but the improvement in quality of life was consistent across all body mass index categories. (Circulation. 2008;117:2583-2590.)

AB - Background Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated atrial fibrillation in obese patients. Methods and Results Five hundred twenty-three consecutive patients with symptomatic, medication-refractory atrial fibrillation underwent catheter ablation. Patients were grouped by body mass index (lean, <25 kg/m2; overweight, 25 to 29.9 kg/m2; obese, <30 kg/m2). Outcome and quality of life were measured with a general health survey (Medical Outcomes Study 36-item Short-Form General Health Survey [SF-36]); patients were assessed before ablation and at 3 and 12 months after the procedure. Two hundred twenty-eight study patients (44%) were overweight, and 201 (38%) were obese. Twelve months after curative ablation, 72% of patients were free of atrial fibrillation without the use of antiarrhythmic agents; 84% were arrhythmia free when those receiving medication were included. Atrial fibrillation was eliminated in 75%, 72%, and 70% of the lean, overweight, and obese patients, respectively, at 12 months (P>0.41, trend test). SF-36 scores were lower for patients with higher body mass index (P<0.05) at baseline. SF-36 scores improved in every functional domain for all body mass index groups after ablation. The mean SF-36 total physical score increased from 59±20 at baseline to 77±19 in 12 months (P<0.001). The total mental health score improved from 66±18 to 79±16 in 12 months (P <0.001). Conclusions Catheter ablation of atrial fibrillation was effective in obese patients. Coexistence of atrial fibrillation and obesity indicated lower SF-36 scores, but the improvement in quality of life was consistent across all body mass index categories. (Circulation. 2008;117:2583-2590.)

KW - Atrial fibrillation

KW - Catheter ablation

KW - Obesity

KW - Quality of life

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