Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: A case series

Amit Chopra; Piyush Das; Abhishek Rai; Preetha Sharone Kuppuswamy; Xiofan Li; John Huston; Kemuel Philbrick; Christopher Sola

doi:10.1016/j.genhosppsych.2011.08.008

Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: A case series

Amit Chopra, Piyush Das, Abhishek Rai, Preetha Sharone Kuppuswamy, Xiofan Li, John Huston, Kemuel Philbrick, Christopher Sola

Radiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in these patients after reducing the tacrolimus dosage or switching it to alternative immunosuppressants. Catatonia symptoms in organ transplant patients should alert clinicians to look for tacrolimus-induced neurotoxicity despite normal serum tacrolimus levels and neuroimaging findings.

Original language	English (US)
Pages (from-to)	209.e9-209.e11
Journal	General Hospital Psychiatry
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/j.genhosppsych.2011.08.008
State	Published - Mar 2012

Keywords

Catatonia
Neurotoxicity
Tacrolimus

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1016/j.genhosppsych.2011.08.008

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title = "Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: A case series",

abstract = "Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in these patients after reducing the tacrolimus dosage or switching it to alternative immunosuppressants. Catatonia symptoms in organ transplant patients should alert clinicians to look for tacrolimus-induced neurotoxicity despite normal serum tacrolimus levels and neuroimaging findings.",

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AU - Chopra, Amit

AU - Das, Piyush

AU - Rai, Abhishek

AU - Kuppuswamy, Preetha Sharone

AU - Li, Xiofan

AU - Huston, John

AU - Philbrick, Kemuel

AU - Sola, Christopher

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AB - Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in these patients after reducing the tacrolimus dosage or switching it to alternative immunosuppressants. Catatonia symptoms in organ transplant patients should alert clinicians to look for tacrolimus-induced neurotoxicity despite normal serum tacrolimus levels and neuroimaging findings.

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Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: A case series

Abstract

Keywords

ASJC Scopus subject areas

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