Catastrophic primary central nervous system vasculitis

Carlo Salvarani, Robert D Jr. Brown, Jonathan M. Morris, John III Huston, Gene G. Hunder

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Primary central nervous system vasculitis (PCNSV) is an uncommon condition that affects the brain and the spinal cord. It is heterogeneous in presenting characteristics and outcomes. We report a patient with a catastrophic rapidly progressive course refractory to intensive treatment with pulses of methylprednisolone and iv cyclophosphamide. The condition rapidly deteriorated and the patient died 6 weeks after presentation. Rapidly progressive PCNSV represents the worst end of the clinical spectrum of PCNSV. These patients are characterised by bilateral, multiple, large cerebral vessel lesions on angiograms and multiple bilateral cerebral infarctions.

Original languageEnglish (US)
JournalClinical and Experimental Rheumatology
Volume32
Issue numberSUPPL.82
StatePublished - 2014

Fingerprint

Central Nervous System Vasculitis
Cerebral Infarction
Methylprednisolone
Cyclophosphamide
Spinal Cord
Angiography
Brain
Therapeutics

Keywords

  • Infarcts
  • Large vessels
  • Primary central nervous system vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Catastrophic primary central nervous system vasculitis. / Salvarani, Carlo; Brown, Robert D Jr.; Morris, Jonathan M.; Huston, John III; Hunder, Gene G.

In: Clinical and Experimental Rheumatology, Vol. 32, No. SUPPL.82, 2014.

Research output: Contribution to journalArticle

Salvarani, Carlo ; Brown, Robert D Jr. ; Morris, Jonathan M. ; Huston, John III ; Hunder, Gene G. / Catastrophic primary central nervous system vasculitis. In: Clinical and Experimental Rheumatology. 2014 ; Vol. 32, No. SUPPL.82.
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