Abstract
A case of Castleman's disease in a patient with type I neurofibromatosis and pheochromocytoma is reported. The association of pheochromocytoma and neurofibromatosis is well documented, but uncommon. Castleman's disease has not been previously documented in a patient with neurofibromatosis or pheochromocytoma and may represent a previously unrecognized association of this disease. Castleman's disease is an interleukin-6 (IL-6) mediated B-cell proliferation. We postulate a relationship between pheochromocytoma IL-6 secretion and Castleman's disease. The relevant literature relating to this unusual case is reviewed.
Original language | English (US) |
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Pages (from-to) | 551-556 |
Number of pages | 6 |
Journal | Leukemia and Lymphoma |
Volume | 27 |
Issue number | 5-6 |
DOIs | |
State | Published - 1997 |
Keywords
- Castleman's disease
- Neurofibromatosis
- Pheochromocytoma
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research