Caspases and caspase inhibitors

Pascal Villa, Scott H. Kaufmann, William C. Earnshaw

Research output: Contribution to journalReview articlepeer-review

540 Scopus citations

Abstract

Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine aspartases (caspases) has come under intensive study, This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and pharmacological caspase inhibitors.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalTrends in biochemical sciences
Volume22
Issue number10
DOIs
StatePublished - Oct 1 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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