UpdateThis article was updated on January 14, 2020, because of a previous error. On page 1, in the Abstract and the section entitled "Case Reports," the word that had read "Genentech" now reads "Genetech."Case:The use of biologics is rapidly expanding. Over the past decade, there has been a significant increase in the number of cash-based "stem cell"/regenerative medicine clinics in the United States. These clinics provide cash-based services touting stem cell injections to cure a myriad of conditions. Largely, these clinics are unregulated and using injections in a non-Food and Drug Administration-approved manner. We report on 2 patients who presented with symptoms suggestive of septic arthritis following stem cell injections by cash-based local stem cell clinics. Case 1 involved a patient who developed septic arthritis following an injection of umbilical cord blood-derived cellular products (Genetech) and required an antibiotic spacer followed by a total hip arthroplasty. Case 2 involved a patient who developed a likely immune-mediated reaction following an injection of morselized human placental allograft tissue by a local chiropractic office at a cost of approximately $8,000.Conclusions:We present these cases to bring increased awareness to the issue and call for increased regulation of this practice.
ASJC Scopus subject areas
- Orthopedics and Sports Medicine