Case Report: Opsoclonus-Myoclonus Syndrome Associated With Contactin-Associated Protein-Like 2 and Acetylcholine Receptor Autoantibodies in the Setting of Non-Small Cell Lung Carcinoma

Christian S. Rosenow, Sara Dawit, Luca P. Farrugia, Katharine A. Henry, MA, Akanksha Sharma, Andrew McKeon, Alyx B. Porter, Marie F. Grill

Research output: Contribution to journalArticlepeer-review

Abstract

Opsoclonus myoclonus syndrome (OMS) is a rare immune-mediated paraneoplastic or para/-post-infectious syndrome characterized by “dancing” eye movements, myoclonus, and ataxia. Neuropsychiatric symptoms have also been reported. Without treatment, OMS may progress to further neurological impairment and even death. Autoimmune attack of CNS structures in OMS is most commonly mediated by anti-Ri (also known as ANNA2) IgG antibodies, with additional findings implicating antibodies targeting various neurotransmitter receptors. Prompt immunotherapy and neoplasm treatment may result in improvement. We report a novel association of Contactin-Associated Protein-Like 2 (Caspr2) antibodies occurring in association with paraneoplastic OMS. While breast cancer and small cell lung cancer (SCLC) are more commonly associated with OMS among adults, we characterize a novel association between Caspr2 antibody in a patient with mixed non-small cell and small cell lung carcinoma.

Original languageEnglish (US)
JournalNeurohospitalist
DOIs
StateAccepted/In press - 2021

Keywords

  • autoimmune diseases of the nervous system
  • clinical specialty
  • clinical specialty
  • cranial nerve diseases
  • nervous system
  • nervous system neoplasms
  • neuroimmunology
  • neurooncology
  • opsoclonus-myoclonus syndrome
  • paraneoplastic syndromes

ASJC Scopus subject areas

  • Clinical Neurology

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