Case of mononeuritis multiplex onset with rituximab therapy for Waldenström's macroglobulinemia

Michelle L. Mauermann, Matthew L. Ryan, Joon Shik Moon, Christopher J. Klein

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Waldenström's macroglobulinemia (WM) is a lymphoplasmacytic disorder with associated monoclonal gammopathy. A wide variety of neuropathies can be associated with WM, but most commonly it is a mild length-dependent sensory neuropathy of unclear etiology. Rituximab is a monoclonal antibody which suppresses mature B-cell populations. It has increasingly been used in wide applications including WM, especially in those cases with severe neuropathy. The highlighted case provides an example of rituximab treatment complication in a WM patient with mild sensory neuropathy that evolved to multiple mononeuropathies with features of systemic vasculitis and unusual conversion of type I to type II cryoglobulinemia.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalJournal of the neurological sciences
Volume260
Issue number1-2
DOIs
StatePublished - Sep 15 2007

Keywords

  • Cryoglobulinemia
  • Mononeuritis multiplex
  • Neuropathy
  • Rituximab
  • Vasculitis
  • Waldenström's macroglobulinemia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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