Case definition in epidemiologic studies of AD/HD

Slavica K Katusic, William J. Barbaresi, Robert C. Colligan, Amy L. Weaver, Cynthia L. Leibson, Steven J. Jacobsen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

PURPOSE: Propose a five-step multigating, multimodal procedure for research case definition and identification of attention-deficit/hyperactivity disorder (AD/HD) in population-based epidemiologic studies. METHODS: Subjects included a birth cohort of all children born between 1976 and 1982 who remained in Rochester after age 5. Screening for AD/HD required 4 steps, using these sources: school/medical records, computerized diagnostic index, and private psychiatry records. In step 5, research criteria were applied to potential cases. The model for defining cases used combinations of three categories of information (DSM-IV, questionnaire, clinical diagnosis). Validity was tested by comparing medication treatment, substance abuse, school outcomes, and comorbidities between cases who did or did not meet DSM-IV criteria. RESULTS: Among 5718 subjects, 1344 potential cases were identified; 379 met research criteria. No difference in gender, treatment, school outcome, or professional making clinical diagnoses was found between cases who did (N = 228) and did not (N = 151) meet DSM-IV criteria. However, cases not meeting DSM-IV criteria were more inattentive (33.8% vs. 17.1%; p < 0.001), older (age 12.8 vs. 10.5 years; p = 0.01), with less substance abuse (15.2% vs. 26.3%; p < 0.001) and psychiatric comorbidities (43.1% vs. 54.4%; p = 0.031). CONCLUSIONS: If only DSM-IV criteria were applied, 151 cases would not have been identified. This study underscores the importance of using multiple sources and combinations of documented information for case definition and identification.

Original languageEnglish (US)
Pages (from-to)430-437
Number of pages8
JournalAnnals of Epidemiology
Volume15
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

Attention Deficit Disorder with Hyperactivity
Diagnostic and Statistical Manual of Mental Disorders
Epidemiologic Studies
Substance-Related Disorders
Psychiatry
Comorbidity
Computerized Medical Records Systems
Research
Parturition
Population
Therapeutics

Keywords

  • AD/HD
  • Attention-Deficit/Hyperactivity Disorder
  • Birth Cohort
  • Epidemiology

ASJC Scopus subject areas

  • Medicine(all)
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Katusic, S. K., Barbaresi, W. J., Colligan, R. C., Weaver, A. L., Leibson, C. L., & Jacobsen, S. J. (2005). Case definition in epidemiologic studies of AD/HD. Annals of Epidemiology, 15(6), 430-437. https://doi.org/10.1016/j.annepidem.2004.12.004

Case definition in epidemiologic studies of AD/HD. / Katusic, Slavica K; Barbaresi, William J.; Colligan, Robert C.; Weaver, Amy L.; Leibson, Cynthia L.; Jacobsen, Steven J.

In: Annals of Epidemiology, Vol. 15, No. 6, 06.2005, p. 430-437.

Research output: Contribution to journalArticle

Katusic, SK, Barbaresi, WJ, Colligan, RC, Weaver, AL, Leibson, CL & Jacobsen, SJ 2005, 'Case definition in epidemiologic studies of AD/HD', Annals of Epidemiology, vol. 15, no. 6, pp. 430-437. https://doi.org/10.1016/j.annepidem.2004.12.004
Katusic SK, Barbaresi WJ, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Case definition in epidemiologic studies of AD/HD. Annals of Epidemiology. 2005 Jun;15(6):430-437. https://doi.org/10.1016/j.annepidem.2004.12.004
Katusic, Slavica K ; Barbaresi, William J. ; Colligan, Robert C. ; Weaver, Amy L. ; Leibson, Cynthia L. ; Jacobsen, Steven J. / Case definition in epidemiologic studies of AD/HD. In: Annals of Epidemiology. 2005 ; Vol. 15, No. 6. pp. 430-437.
@article{15ebdf236beb4929b41d590429305b6a,
title = "Case definition in epidemiologic studies of AD/HD",
abstract = "PURPOSE: Propose a five-step multigating, multimodal procedure for research case definition and identification of attention-deficit/hyperactivity disorder (AD/HD) in population-based epidemiologic studies. METHODS: Subjects included a birth cohort of all children born between 1976 and 1982 who remained in Rochester after age 5. Screening for AD/HD required 4 steps, using these sources: school/medical records, computerized diagnostic index, and private psychiatry records. In step 5, research criteria were applied to potential cases. The model for defining cases used combinations of three categories of information (DSM-IV, questionnaire, clinical diagnosis). Validity was tested by comparing medication treatment, substance abuse, school outcomes, and comorbidities between cases who did or did not meet DSM-IV criteria. RESULTS: Among 5718 subjects, 1344 potential cases were identified; 379 met research criteria. No difference in gender, treatment, school outcome, or professional making clinical diagnoses was found between cases who did (N = 228) and did not (N = 151) meet DSM-IV criteria. However, cases not meeting DSM-IV criteria were more inattentive (33.8{\%} vs. 17.1{\%}; p < 0.001), older (age 12.8 vs. 10.5 years; p = 0.01), with less substance abuse (15.2{\%} vs. 26.3{\%}; p < 0.001) and psychiatric comorbidities (43.1{\%} vs. 54.4{\%}; p = 0.031). CONCLUSIONS: If only DSM-IV criteria were applied, 151 cases would not have been identified. This study underscores the importance of using multiple sources and combinations of documented information for case definition and identification.",
keywords = "AD/HD, Attention-Deficit/Hyperactivity Disorder, Birth Cohort, Epidemiology",
author = "Katusic, {Slavica K} and Barbaresi, {William J.} and Colligan, {Robert C.} and Weaver, {Amy L.} and Leibson, {Cynthia L.} and Jacobsen, {Steven J.}",
year = "2005",
month = "6",
doi = "10.1016/j.annepidem.2004.12.004",
language = "English (US)",
volume = "15",
pages = "430--437",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Case definition in epidemiologic studies of AD/HD

AU - Katusic, Slavica K

AU - Barbaresi, William J.

AU - Colligan, Robert C.

AU - Weaver, Amy L.

AU - Leibson, Cynthia L.

AU - Jacobsen, Steven J.

PY - 2005/6

Y1 - 2005/6

N2 - PURPOSE: Propose a five-step multigating, multimodal procedure for research case definition and identification of attention-deficit/hyperactivity disorder (AD/HD) in population-based epidemiologic studies. METHODS: Subjects included a birth cohort of all children born between 1976 and 1982 who remained in Rochester after age 5. Screening for AD/HD required 4 steps, using these sources: school/medical records, computerized diagnostic index, and private psychiatry records. In step 5, research criteria were applied to potential cases. The model for defining cases used combinations of three categories of information (DSM-IV, questionnaire, clinical diagnosis). Validity was tested by comparing medication treatment, substance abuse, school outcomes, and comorbidities between cases who did or did not meet DSM-IV criteria. RESULTS: Among 5718 subjects, 1344 potential cases were identified; 379 met research criteria. No difference in gender, treatment, school outcome, or professional making clinical diagnoses was found between cases who did (N = 228) and did not (N = 151) meet DSM-IV criteria. However, cases not meeting DSM-IV criteria were more inattentive (33.8% vs. 17.1%; p < 0.001), older (age 12.8 vs. 10.5 years; p = 0.01), with less substance abuse (15.2% vs. 26.3%; p < 0.001) and psychiatric comorbidities (43.1% vs. 54.4%; p = 0.031). CONCLUSIONS: If only DSM-IV criteria were applied, 151 cases would not have been identified. This study underscores the importance of using multiple sources and combinations of documented information for case definition and identification.

AB - PURPOSE: Propose a five-step multigating, multimodal procedure for research case definition and identification of attention-deficit/hyperactivity disorder (AD/HD) in population-based epidemiologic studies. METHODS: Subjects included a birth cohort of all children born between 1976 and 1982 who remained in Rochester after age 5. Screening for AD/HD required 4 steps, using these sources: school/medical records, computerized diagnostic index, and private psychiatry records. In step 5, research criteria were applied to potential cases. The model for defining cases used combinations of three categories of information (DSM-IV, questionnaire, clinical diagnosis). Validity was tested by comparing medication treatment, substance abuse, school outcomes, and comorbidities between cases who did or did not meet DSM-IV criteria. RESULTS: Among 5718 subjects, 1344 potential cases were identified; 379 met research criteria. No difference in gender, treatment, school outcome, or professional making clinical diagnoses was found between cases who did (N = 228) and did not (N = 151) meet DSM-IV criteria. However, cases not meeting DSM-IV criteria were more inattentive (33.8% vs. 17.1%; p < 0.001), older (age 12.8 vs. 10.5 years; p = 0.01), with less substance abuse (15.2% vs. 26.3%; p < 0.001) and psychiatric comorbidities (43.1% vs. 54.4%; p = 0.031). CONCLUSIONS: If only DSM-IV criteria were applied, 151 cases would not have been identified. This study underscores the importance of using multiple sources and combinations of documented information for case definition and identification.

KW - AD/HD

KW - Attention-Deficit/Hyperactivity Disorder

KW - Birth Cohort

KW - Epidemiology

UR - http://www.scopus.com/inward/record.url?scp=20644470921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20644470921&partnerID=8YFLogxK

U2 - 10.1016/j.annepidem.2004.12.004

DO - 10.1016/j.annepidem.2004.12.004

M3 - Article

C2 - 15967390

AN - SCOPUS:20644470921

VL - 15

SP - 430

EP - 437

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 6

ER -