Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

D. M. Maraganore, M. J. Farrer, J. A. Hardy, S. J. Lincoln, S. K. McDonnell, Walter A Rocca

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant: S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorphism carriers had significantly lower risk of PD (odds ratio = 0.53; p = 0.03), and the risk reduction was greater for younger onset cases.

Original languageEnglish (US)
Pages (from-to)1858-1860
Number of pages3
JournalNeurology
Volume53
Issue number8
StatePublished - Nov 10 1999

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Ubiquitin Thiolesterase
Parkinson Disease
Case-Control Studies
Mutation
Risk Reduction Behavior
Genes
Odds Ratio

Keywords

  • Candidate gene
  • PD
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maraganore, D. M., Farrer, M. J., Hardy, J. A., Lincoln, S. J., McDonnell, S. K., & Rocca, W. A. (1999). Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. Neurology, 53(8), 1858-1860.

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. / Maraganore, D. M.; Farrer, M. J.; Hardy, J. A.; Lincoln, S. J.; McDonnell, S. K.; Rocca, Walter A.

In: Neurology, Vol. 53, No. 8, 10.11.1999, p. 1858-1860.

Research output: Contribution to journalArticle

Maraganore, DM, Farrer, MJ, Hardy, JA, Lincoln, SJ, McDonnell, SK & Rocca, WA 1999, 'Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease', Neurology, vol. 53, no. 8, pp. 1858-1860.
Maraganore DM, Farrer MJ, Hardy JA, Lincoln SJ, McDonnell SK, Rocca WA. Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. Neurology. 1999 Nov 10;53(8):1858-1860.
Maraganore, D. M. ; Farrer, M. J. ; Hardy, J. A. ; Lincoln, S. J. ; McDonnell, S. K. ; Rocca, Walter A. / Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. In: Neurology. 1999 ; Vol. 53, No. 8. pp. 1858-1860.
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