Case-control study of the extended tau gene haplotype in Parkinson's disease

Demetrius M. Maraganore; Dena G. Hernandez; Andrew B. Singleton; Matthew J. Farrer; Shannon K. McDonnell; Michael L. Hutton; John A. Hardy; Walter A. Rocca

doi:10.1002/ana.1228

Case-control study of the extended tau gene haplotype in Parkinson's disease

Demetrius M. Maraganore, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Shannon K. McDonnell, Michael L. Hutton, John A. Hardy, Walter A. Rocca

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.

Original language	English (US)
Pages (from-to)	658-661
Number of pages	4
Journal	Annals of neurology
Volume	50
Issue number	5
DOIs	https://doi.org/10.1002/ana.1228
State	Published - 2001

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Case-control study of the extended tau gene haplotype in Parkinson's disease",

abstract = "We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.",

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AU - Hernandez, Dena G.

AU - Singleton, Andrew B.

AU - Farrer, Matthew J.

AU - McDonnell, Shannon K.

AU - Hutton, Michael L.

AU - Hardy, John A.

AU - Rocca, Walter A.

PY - 2001

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AB - We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.

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Case-control study of the extended tau gene haplotype in Parkinson's disease

Abstract

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