Case-control study of the extended tau gene haplotype in Parkinson's disease

Demetrius M. Maraganore, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Shannon K. McDonnell, Michael L. Hutton, John A. Hardy, Walter A. Rocca

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.

Original languageEnglish (US)
Pages (from-to)658-661
Number of pages4
JournalAnnals of neurology
Volume50
Issue number5
DOIs
StatePublished - Nov 12 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Maraganore, D. M., Hernandez, D. G., Singleton, A. B., Farrer, M. J., McDonnell, S. K., Hutton, M. L., Hardy, J. A., & Rocca, W. A. (2001). Case-control study of the extended tau gene haplotype in Parkinson's disease. Annals of neurology, 50(5), 658-661. https://doi.org/10.1002/ana.1228