Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

Demetrius M. Maraganore; Matthew J. Farrer; Timothy G. Lesnick; Mariza de Andrade; James H. Bower; Dena Hernandez; John A. Hardy; Walter A. Rocca

doi:10.1002/mds.10547

Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, Timothy G. Lesnick, Mariza de Andrade, James H. Bower, Dena Hernandez, John A. Hardy, Walter A. Rocca

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We conducted a case-control study of the α-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5′ terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the α-synuclein gene (SNCA) or the parkin (PARK2) gene.

Original language	English (US)
Pages (from-to)	1233-1239
Number of pages	7
Journal	Movement Disorders
Volume	18
Issue number	11
DOIs	https://doi.org/10.1002/mds.10547
State	Published - Nov 2003

Keywords

Alpha-synuclein
Association
Interactions
Parkin
Parkinson's disease
Susceptibility genes
Synphilin-1

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Case-control study of the α-synuclein interacting protein gene and Parkinson's disease",

abstract = "We conducted a case-control study of the α-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5′ terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the α-synuclein gene (SNCA) or the parkin (PARK2) gene.",

keywords = "Alpha-synuclein, Association, Interactions, Parkin, Parkinson's disease, Susceptibility genes, Synphilin-1",

author = "Maraganore, {Demetrius M.} and Farrer, {Matthew J.} and Lesnick, {Timothy G.} and {de Andrade}, Mariza and Bower, {James H.} and Dena Hernandez and Hardy, {John A.} and Rocca, {Walter A.}",

year = "2003",

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volume = "18",

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AU - Maraganore, Demetrius M.

AU - Farrer, Matthew J.

AU - Lesnick, Timothy G.

AU - de Andrade, Mariza

AU - Bower, James H.

AU - Hernandez, Dena

AU - Hardy, John A.

AU - Rocca, Walter A.

PY - 2003/11

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N2 - We conducted a case-control study of the α-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5′ terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the α-synuclein gene (SNCA) or the parkin (PARK2) gene.

AB - We conducted a case-control study of the α-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5′ terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the α-synuclein gene (SNCA) or the parkin (PARK2) gene.

KW - Alpha-synuclein

KW - Association

KW - Interactions

KW - Parkin

KW - Parkinson's disease

KW - Susceptibility genes

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Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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