Case-control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia

Marian Pavuk, James R Cerhan, Charles F. Lynch, Anton Kocan, Jan Petrik, Jana Chovancova

Research output: Contribution to journalArticle

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Abstract

This case-control study was designed to investigate association between polychlorinated biphenyls (PCBs) and risk of breast cancer in an area of high environmental exposure in the Michalovce district of eastern Slovakia. Incident breast cancer cases from the Michalovce district diagnosed between May 1997 and May 1999 were recruited through the Oncology Department of the District Hospital. A total of 15 individual PCB congeners, 2,2′-bis(4-chlorophenyl)-1,1-dichloroethylene (DDE), 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT), and hexachlorobenzene (HCB) were measured in the serum of 24 breast cancer patients and 88 population controls in 1998-1999. The median levels of total PCBs were similar in cases (2586 ng/g of lipid) and controls (2682ng/g of lipid). Higher serum levels (highest vs. lowest tertile) of total PCBs (odds ratio (OR)=0.42, 95% CI 0.10-1.82, p-for trend=0.31), group I congeners (OR=0.37, 95% CI 0.10-1.43, P-for trend=0.02), group 2 congeners (OR=0.32, 95% CI 0.07-1.56, P-for trend=0.60), and group 3 congeners (OR=0.49, 95% CI 0.12-2.04, P-for trend=0.51) were inversely associated with risk of breast cancer. Higher serum levels of DDE (OR=3.04, 95% CI 0.65-14.3, P-for trend=0.10) were positively associated with risk of breast cancer, while there was no association for DDT (OR= 1.19, 95% CI 0.27-5.23, P-for trend=0.68), and an inverse association for HCB (OR=0.45, 95% CI 0.06-3.19, P-for trend = 0.67). While generally not statistically significant, PCB and HCB levels were inversely associated with risk of breast cancer in this highly exposed population. DDE, but not DDT, was positively associated with risk.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalJournal of Exposure Analysis and Environmental Epidemiology
Volume13
Issue number4
DOIs
StatePublished - Jul 2003

Fingerprint

Slovakia
Polychlorinated Biphenyls
Polychlorinated biphenyls
organochlorine
Case-Control Studies
PCB
cancer
Hexachlorobenzene
Dichlorodiphenyl Dichloroethylene
Odds Ratio
DDT
Breast Neoplasms
hexachlorobenzene
DDE
Lipids
serum
Oncology
lipid
Serum
Population Control

Keywords

  • Breast cancer
  • DDE
  • Environmental epidemiology
  • PCB

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Case-control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia. / Pavuk, Marian; Cerhan, James R; Lynch, Charles F.; Kocan, Anton; Petrik, Jan; Chovancova, Jana.

In: Journal of Exposure Analysis and Environmental Epidemiology, Vol. 13, No. 4, 07.2003, p. 267-275.

Research output: Contribution to journalArticle

Pavuk, Marian ; Cerhan, James R ; Lynch, Charles F. ; Kocan, Anton ; Petrik, Jan ; Chovancova, Jana. / Case-control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia. In: Journal of Exposure Analysis and Environmental Epidemiology. 2003 ; Vol. 13, No. 4. pp. 267-275.
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N2 - This case-control study was designed to investigate association between polychlorinated biphenyls (PCBs) and risk of breast cancer in an area of high environmental exposure in the Michalovce district of eastern Slovakia. Incident breast cancer cases from the Michalovce district diagnosed between May 1997 and May 1999 were recruited through the Oncology Department of the District Hospital. A total of 15 individual PCB congeners, 2,2′-bis(4-chlorophenyl)-1,1-dichloroethylene (DDE), 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT), and hexachlorobenzene (HCB) were measured in the serum of 24 breast cancer patients and 88 population controls in 1998-1999. The median levels of total PCBs were similar in cases (2586 ng/g of lipid) and controls (2682ng/g of lipid). Higher serum levels (highest vs. lowest tertile) of total PCBs (odds ratio (OR)=0.42, 95% CI 0.10-1.82, p-for trend=0.31), group I congeners (OR=0.37, 95% CI 0.10-1.43, P-for trend=0.02), group 2 congeners (OR=0.32, 95% CI 0.07-1.56, P-for trend=0.60), and group 3 congeners (OR=0.49, 95% CI 0.12-2.04, P-for trend=0.51) were inversely associated with risk of breast cancer. Higher serum levels of DDE (OR=3.04, 95% CI 0.65-14.3, P-for trend=0.10) were positively associated with risk of breast cancer, while there was no association for DDT (OR= 1.19, 95% CI 0.27-5.23, P-for trend=0.68), and an inverse association for HCB (OR=0.45, 95% CI 0.06-3.19, P-for trend = 0.67). While generally not statistically significant, PCB and HCB levels were inversely associated with risk of breast cancer in this highly exposed population. DDE, but not DDT, was positively associated with risk.

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