Case-control study of estrogen receptor gene polymorphism in Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, Shannon K. McDonnell, Alexis Elbaz, Daniel J. Schaid, John A. Hardy, Walter A. Rocca

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We investigated the association of Parkinson's disease (PD) with two estrogen receptor gene polymorphisms. In a sample of 319 unrelated PD cases and 196 control subjects including both men and women, we observed no association of PD with the estrogen receptor genotypes derived from XbaI and PvuII digests. Analyses restricted to women or to cases and controls of European origin yielded similar findings. Further analyses stratified by age at examination or by family history did not show associations. While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility.

Original languageEnglish (US)
Pages (from-to)509-512
Number of pages4
JournalMovement Disorders
Volume17
Issue number3
DOIs
StatePublished - May 2002

Keywords

  • Case-control study
  • Epidemiology
  • Estrogen
  • Parkinson's disease
  • Polymorphims
  • Susceptibiltiy genes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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