Case-control study of estrogen receptor gene polymorphism in Parkinson's disease

Demetrius M. Maraganore; Matthew J. Farrer; Shannon K. McDonnell; Alexis Elbaz; Daniel J. Schaid; John A. Hardy; Walter A. Rocca

doi:10.1002/mds.1253

Case-control study of estrogen receptor gene polymorphism in Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, Shannon K. McDonnell, Alexis Elbaz, Daniel J. Schaid, John A. Hardy, Walter A. Rocca

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We investigated the association of Parkinson's disease (PD) with two estrogen receptor gene polymorphisms. In a sample of 319 unrelated PD cases and 196 control subjects including both men and women, we observed no association of PD with the estrogen receptor genotypes derived from XbaI and PvuII digests. Analyses restricted to women or to cases and controls of European origin yielded similar findings. Further analyses stratified by age at examination or by family history did not show associations. While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility.

Original language	English (US)
Pages (from-to)	509-512
Number of pages	4
Journal	Movement Disorders
Volume	17
Issue number	3
DOIs	https://doi.org/10.1002/mds.1253
State	Published - May 2002

Keywords

Case-control study
Epidemiology
Estrogen
Parkinson's disease
Polymorphims
Susceptibiltiy genes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.1253

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title = "Case-control study of estrogen receptor gene polymorphism in Parkinson's disease",

abstract = "We investigated the association of Parkinson's disease (PD) with two estrogen receptor gene polymorphisms. In a sample of 319 unrelated PD cases and 196 control subjects including both men and women, we observed no association of PD with the estrogen receptor genotypes derived from XbaI and PvuII digests. Analyses restricted to women or to cases and controls of European origin yielded similar findings. Further analyses stratified by age at examination or by family history did not show associations. While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility.",

keywords = "Case-control study, Epidemiology, Estrogen, Parkinson's disease, Polymorphims, Susceptibiltiy genes",

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AU - Maraganore, Demetrius M.

AU - Farrer, Matthew J.

AU - McDonnell, Shannon K.

AU - Elbaz, Alexis

AU - Schaid, Daniel J.

AU - Hardy, John A.

AU - Rocca, Walter A.

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AB - We investigated the association of Parkinson's disease (PD) with two estrogen receptor gene polymorphisms. In a sample of 319 unrelated PD cases and 196 control subjects including both men and women, we observed no association of PD with the estrogen receptor genotypes derived from XbaI and PvuII digests. Analyses restricted to women or to cases and controls of European origin yielded similar findings. Further analyses stratified by age at examination or by family history did not show associations. While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility.

KW - Case-control study

KW - Epidemiology

KW - Estrogen

KW - Parkinson's disease

KW - Polymorphims

KW - Susceptibiltiy genes

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Case-control study of estrogen receptor gene polymorphism in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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