Cartilage injury and repair

S. C. Ghivizzani, T. J. Oligino, P. D. Robbins, Christopher H Evans

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to regenerate tissue with the appropriate macromolecular constituents and architecture of normal hyaline cartilage. Although full- thickness defects are capable of stimulating a repair response, the resulting fibrocartilage is inferior and cannot withstand long-term, repetitive use. Numerous surgical approaches that involve penetration of subchondral bone offer short-term to moderate-term relief of symptoms, whereas other approaches have seen significant improvement through transplantation of osteochondral and periosteal tissue and implantation of autologous chondrocytes. Despite these procedures, articular cartilage damage continues to be an unmet clinical problem. Improvements in biochemical and molecular biologic techniques may allow advances in the understanding of chondrocyte and cartilage biology and may provide innovative and novel approaches to stimulating the repair of articular cartilage through biologic means.

Original languageEnglish (US)
Pages (from-to)289-307
Number of pages19
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume11
Issue number2
StatePublished - 2000
Externally publishedYes

Fingerprint

Articular Cartilage
Cartilage
Chondrocytes
Wounds and Injuries
Fibrocartilage
Hyaline Cartilage
Transplantation
Bone and Bones

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Ghivizzani, S. C., Oligino, T. J., Robbins, P. D., & Evans, C. H. (2000). Cartilage injury and repair. Physical Medicine and Rehabilitation Clinics of North America, 11(2), 289-307.

Cartilage injury and repair. / Ghivizzani, S. C.; Oligino, T. J.; Robbins, P. D.; Evans, Christopher H.

In: Physical Medicine and Rehabilitation Clinics of North America, Vol. 11, No. 2, 2000, p. 289-307.

Research output: Contribution to journalArticle

Ghivizzani, SC, Oligino, TJ, Robbins, PD & Evans, CH 2000, 'Cartilage injury and repair', Physical Medicine and Rehabilitation Clinics of North America, vol. 11, no. 2, pp. 289-307.
Ghivizzani, S. C. ; Oligino, T. J. ; Robbins, P. D. ; Evans, Christopher H. / Cartilage injury and repair. In: Physical Medicine and Rehabilitation Clinics of North America. 2000 ; Vol. 11, No. 2. pp. 289-307.
@article{6f7666a4cae04f7fabfab58481d7acc5,
title = "Cartilage injury and repair",
abstract = "Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to regenerate tissue with the appropriate macromolecular constituents and architecture of normal hyaline cartilage. Although full- thickness defects are capable of stimulating a repair response, the resulting fibrocartilage is inferior and cannot withstand long-term, repetitive use. Numerous surgical approaches that involve penetration of subchondral bone offer short-term to moderate-term relief of symptoms, whereas other approaches have seen significant improvement through transplantation of osteochondral and periosteal tissue and implantation of autologous chondrocytes. Despite these procedures, articular cartilage damage continues to be an unmet clinical problem. Improvements in biochemical and molecular biologic techniques may allow advances in the understanding of chondrocyte and cartilage biology and may provide innovative and novel approaches to stimulating the repair of articular cartilage through biologic means.",
author = "Ghivizzani, {S. C.} and Oligino, {T. J.} and Robbins, {P. D.} and Evans, {Christopher H}",
year = "2000",
language = "English (US)",
volume = "11",
pages = "289--307",
journal = "Physical Medicine and Rehabilitation Clinics of North America",
issn = "1047-9651",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Cartilage injury and repair

AU - Ghivizzani, S. C.

AU - Oligino, T. J.

AU - Robbins, P. D.

AU - Evans, Christopher H

PY - 2000

Y1 - 2000

N2 - Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to regenerate tissue with the appropriate macromolecular constituents and architecture of normal hyaline cartilage. Although full- thickness defects are capable of stimulating a repair response, the resulting fibrocartilage is inferior and cannot withstand long-term, repetitive use. Numerous surgical approaches that involve penetration of subchondral bone offer short-term to moderate-term relief of symptoms, whereas other approaches have seen significant improvement through transplantation of osteochondral and periosteal tissue and implantation of autologous chondrocytes. Despite these procedures, articular cartilage damage continues to be an unmet clinical problem. Improvements in biochemical and molecular biologic techniques may allow advances in the understanding of chondrocyte and cartilage biology and may provide innovative and novel approaches to stimulating the repair of articular cartilage through biologic means.

AB - Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to regenerate tissue with the appropriate macromolecular constituents and architecture of normal hyaline cartilage. Although full- thickness defects are capable of stimulating a repair response, the resulting fibrocartilage is inferior and cannot withstand long-term, repetitive use. Numerous surgical approaches that involve penetration of subchondral bone offer short-term to moderate-term relief of symptoms, whereas other approaches have seen significant improvement through transplantation of osteochondral and periosteal tissue and implantation of autologous chondrocytes. Despite these procedures, articular cartilage damage continues to be an unmet clinical problem. Improvements in biochemical and molecular biologic techniques may allow advances in the understanding of chondrocyte and cartilage biology and may provide innovative and novel approaches to stimulating the repair of articular cartilage through biologic means.

UR - http://www.scopus.com/inward/record.url?scp=0034104383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034104383&partnerID=8YFLogxK

M3 - Article

C2 - 10810762

AN - SCOPUS:0034104383

VL - 11

SP - 289

EP - 307

JO - Physical Medicine and Rehabilitation Clinics of North America

JF - Physical Medicine and Rehabilitation Clinics of North America

SN - 1047-9651

IS - 2

ER -