Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events

L. Saba, G. Micheletti, W. Brinjikji, P. Garofalo, R. Montisci, A. Balestrieri, J. S. Suri, J. K. DeMarco, G. Lanzino, R. Sanfilippo

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Our aim was to assess the relationship between volume and percentage of intraplaque hemorrhage measured using CT and the occurrence of cerebrovascular events at the time of CT. MATERIALS AND METHODS: One-hundred-twenty-three consecutive subjects (246 carotid arteries) with a mean age of 69 years who underwent CTA were included in this retrospective study. Plaque volume of components and subcomponents (including intraplaque hemorrhage volume) was quantified with dedicated software. RESULTS: Forty-six arteries were excluded because no plaque was identified. In the remaining 200 carotid arteries, a statistically significant difference was found between presentation with cerebrovascular events and lipid volume (P = .002), intraplaque hemorrhage volume (P = .002), percentage of lipid (P = .002), percentage of calcium (P = .001), percentage of intraplaque hemorrhage (P = .001), percentage of lipid-intraplaque hemorrhage (P = .001), and intraplaque hemorrhage/lipid ratio (P = .001). The highest receiver operating characteristic area under the curve was obtained with the intraplaque hemorrhage volume with a value of 0.793 (P = .001), percentage of intraplaque hemorrhage with an area under the curve of 0.812 (P = .001), and the intraplaque hemorrhage/lipid ratio with an area under the curve value of 0.811 (P = .001). CONCLUSIONS: Results of our study suggest that Hounsfield unit values <25 have a statistically significant association with the presence of cerebrovascular events and that the ratio intraplaque hemorrhage/lipid volume represents a strong parameter for the association of cerebrovascular events.

Original languageEnglish (US)
Pages (from-to)1731-1737
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume40
Issue number10
DOIs
StatePublished - Jan 1 2019

Fingerprint

Hemorrhage
Lipids
Area Under Curve
Carotid Arteries
ROC Curve
Software
Retrospective Studies
Arteries
Calcium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Saba, L., Micheletti, G., Brinjikji, W., Garofalo, P., Montisci, R., Balestrieri, A., ... Sanfilippo, R. (2019). Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events. American Journal of Neuroradiology, 40(10), 1731-1737. https://doi.org/10.3174/ajnr.A6189

Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events. / Saba, L.; Micheletti, G.; Brinjikji, W.; Garofalo, P.; Montisci, R.; Balestrieri, A.; Suri, J. S.; DeMarco, J. K.; Lanzino, G.; Sanfilippo, R.

In: American Journal of Neuroradiology, Vol. 40, No. 10, 01.01.2019, p. 1731-1737.

Research output: Contribution to journalArticle

Saba, L, Micheletti, G, Brinjikji, W, Garofalo, P, Montisci, R, Balestrieri, A, Suri, JS, DeMarco, JK, Lanzino, G & Sanfilippo, R 2019, 'Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events', American Journal of Neuroradiology, vol. 40, no. 10, pp. 1731-1737. https://doi.org/10.3174/ajnr.A6189
Saba, L. ; Micheletti, G. ; Brinjikji, W. ; Garofalo, P. ; Montisci, R. ; Balestrieri, A. ; Suri, J. S. ; DeMarco, J. K. ; Lanzino, G. ; Sanfilippo, R. / Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events. In: American Journal of Neuroradiology. 2019 ; Vol. 40, No. 10. pp. 1731-1737.
@article{589eeb245f964f629c241aa4dfdc2f28,
title = "Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events",
abstract = "BACKGROUND AND PURPOSE: Our aim was to assess the relationship between volume and percentage of intraplaque hemorrhage measured using CT and the occurrence of cerebrovascular events at the time of CT. MATERIALS AND METHODS: One-hundred-twenty-three consecutive subjects (246 carotid arteries) with a mean age of 69 years who underwent CTA were included in this retrospective study. Plaque volume of components and subcomponents (including intraplaque hemorrhage volume) was quantified with dedicated software. RESULTS: Forty-six arteries were excluded because no plaque was identified. In the remaining 200 carotid arteries, a statistically significant difference was found between presentation with cerebrovascular events and lipid volume (P = .002), intraplaque hemorrhage volume (P = .002), percentage of lipid (P = .002), percentage of calcium (P = .001), percentage of intraplaque hemorrhage (P = .001), percentage of lipid-intraplaque hemorrhage (P = .001), and intraplaque hemorrhage/lipid ratio (P = .001). The highest receiver operating characteristic area under the curve was obtained with the intraplaque hemorrhage volume with a value of 0.793 (P = .001), percentage of intraplaque hemorrhage with an area under the curve of 0.812 (P = .001), and the intraplaque hemorrhage/lipid ratio with an area under the curve value of 0.811 (P = .001). CONCLUSIONS: Results of our study suggest that Hounsfield unit values <25 have a statistically significant association with the presence of cerebrovascular events and that the ratio intraplaque hemorrhage/lipid volume represents a strong parameter for the association of cerebrovascular events.",
author = "L. Saba and G. Micheletti and W. Brinjikji and P. Garofalo and R. Montisci and A. Balestrieri and Suri, {J. S.} and DeMarco, {J. K.} and G. Lanzino and R. Sanfilippo",
year = "2019",
month = "1",
day = "1",
doi = "10.3174/ajnr.A6189",
language = "English (US)",
volume = "40",
pages = "1731--1737",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "10",

}

TY - JOUR

T1 - Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events

AU - Saba, L.

AU - Micheletti, G.

AU - Brinjikji, W.

AU - Garofalo, P.

AU - Montisci, R.

AU - Balestrieri, A.

AU - Suri, J. S.

AU - DeMarco, J. K.

AU - Lanzino, G.

AU - Sanfilippo, R.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND AND PURPOSE: Our aim was to assess the relationship between volume and percentage of intraplaque hemorrhage measured using CT and the occurrence of cerebrovascular events at the time of CT. MATERIALS AND METHODS: One-hundred-twenty-three consecutive subjects (246 carotid arteries) with a mean age of 69 years who underwent CTA were included in this retrospective study. Plaque volume of components and subcomponents (including intraplaque hemorrhage volume) was quantified with dedicated software. RESULTS: Forty-six arteries were excluded because no plaque was identified. In the remaining 200 carotid arteries, a statistically significant difference was found between presentation with cerebrovascular events and lipid volume (P = .002), intraplaque hemorrhage volume (P = .002), percentage of lipid (P = .002), percentage of calcium (P = .001), percentage of intraplaque hemorrhage (P = .001), percentage of lipid-intraplaque hemorrhage (P = .001), and intraplaque hemorrhage/lipid ratio (P = .001). The highest receiver operating characteristic area under the curve was obtained with the intraplaque hemorrhage volume with a value of 0.793 (P = .001), percentage of intraplaque hemorrhage with an area under the curve of 0.812 (P = .001), and the intraplaque hemorrhage/lipid ratio with an area under the curve value of 0.811 (P = .001). CONCLUSIONS: Results of our study suggest that Hounsfield unit values <25 have a statistically significant association with the presence of cerebrovascular events and that the ratio intraplaque hemorrhage/lipid volume represents a strong parameter for the association of cerebrovascular events.

AB - BACKGROUND AND PURPOSE: Our aim was to assess the relationship between volume and percentage of intraplaque hemorrhage measured using CT and the occurrence of cerebrovascular events at the time of CT. MATERIALS AND METHODS: One-hundred-twenty-three consecutive subjects (246 carotid arteries) with a mean age of 69 years who underwent CTA were included in this retrospective study. Plaque volume of components and subcomponents (including intraplaque hemorrhage volume) was quantified with dedicated software. RESULTS: Forty-six arteries were excluded because no plaque was identified. In the remaining 200 carotid arteries, a statistically significant difference was found between presentation with cerebrovascular events and lipid volume (P = .002), intraplaque hemorrhage volume (P = .002), percentage of lipid (P = .002), percentage of calcium (P = .001), percentage of intraplaque hemorrhage (P = .001), percentage of lipid-intraplaque hemorrhage (P = .001), and intraplaque hemorrhage/lipid ratio (P = .001). The highest receiver operating characteristic area under the curve was obtained with the intraplaque hemorrhage volume with a value of 0.793 (P = .001), percentage of intraplaque hemorrhage with an area under the curve of 0.812 (P = .001), and the intraplaque hemorrhage/lipid ratio with an area under the curve value of 0.811 (P = .001). CONCLUSIONS: Results of our study suggest that Hounsfield unit values <25 have a statistically significant association with the presence of cerebrovascular events and that the ratio intraplaque hemorrhage/lipid volume represents a strong parameter for the association of cerebrovascular events.

UR - http://www.scopus.com/inward/record.url?scp=85073090163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073090163&partnerID=8YFLogxK

U2 - 10.3174/ajnr.A6189

DO - 10.3174/ajnr.A6189

M3 - Article

C2 - 31558503

AN - SCOPUS:85073090163

VL - 40

SP - 1731

EP - 1737

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 10

ER -