Carnitine transport in cultured muscle cells and skin fibroblasts from patients with primary systemic carnitine deficiency

Charles J. Rebouche, Andrew G. Engel

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

l-Carnitine transport was studied in cultured muscle cells and skin fibroblasts of patients with primary systemic carnitine deficiency and control subjects. In both cell culture types, two systems for carnitine transport were identified. The kinetic parameters for carnitine transport were remarkably similar in cultured muscle cells and skin fibroblasts. Normal rates and kinetic properties of carnitine transport were observed for both cell lines from patients with systemic carnitine deficiency. These studies do not rule out a defect in carnitine transport in vivo.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalIn Vitro
Volume18
Issue number5
DOIs
StatePublished - May 1 1982

Keywords

  • carnitine
  • carnitine transport
  • muscle cell culture
  • primary systemic carnitine deficiency
  • skin fibroblasts

ASJC Scopus subject areas

  • Biotechnology
  • Plant Science

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