Caregiver assessment of patients depression in alzheimer disease: Longitudinal analysis in a drug treatment study

Paul B. Rosenberg, Michelle M Mielke, Constantine G. Lyketsos

Research output: Contribution to journalArticle

26 Scopus citations


OBJECTIVE: Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input. METHODS: In a 12-week, controlled, clinical trial of sertraline in depressed AD patients, authors correlated caregiver mood and subjective burden on several patient mood measures, incorporating varied degrees of caregiver input. RESULTS: Caregiver variables accounted for up to 33% of the variance in patient mood ratings. Caregiver depression and burden decreased regardless of treatment assignment. CONCLUSION: Caregiver depression and burden affect their rating of AD patients mood, but the majority of variance is due to patient characteristics. 00019442-200509000-00012.

Original languageEnglish (US)
Pages (from-to)822-826
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Issue number9
StatePublished - 2005
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

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