TY - JOUR
T1 - Cardiovascular variability characteristics in obstructive sleep apnea
AU - Narkiewicz, Krzysztof
AU - Somers, Virend K.
N1 - Funding Information:
Dr. Narkiewicz was a recipient of a Fogarty Fellowship (NIH 3F05 TW05200) and a Perkins Memorial Award from the American Physiological Society. Dr. Somers is an Established Investigator of the American Heart Association and is also supported by NIH HL 61560, HL 65176 and M01-RR00585. The authors also acknowledge the support of NIH FIRCA RO3 TWO 1148, and are grateful to their colleagues who contributed to the studies described in this review.
PY - 2001/7/20
Y1 - 2001/7/20
N2 - Patients with obstructive sleep apnea (OSA) are at increased risk for cardiovascular disease. Altered cardiovascular variability is a prognostic indicator for cardiovascular events. This review examines the evidence that OSA is accompanied by alterations in cardiovascular variability. This alteration is evident even in the absence of hypertension, heart failure or other disease states, and may be linked to the severity of OSA. The presence of clear-cut abnormalities in time and frequency-domain measures of blood-pressure and heart-rate variability in normotensive OSA patients provides intriguing evidence for the concept of an etiologic interaction between sleep apnea and cardiovascular disease. Mechanisms that could contribute to altered cardiovascular variability in patients with sleep apnea include abnormalities in chemoreflex, baroreflex and endothelial function.
AB - Patients with obstructive sleep apnea (OSA) are at increased risk for cardiovascular disease. Altered cardiovascular variability is a prognostic indicator for cardiovascular events. This review examines the evidence that OSA is accompanied by alterations in cardiovascular variability. This alteration is evident even in the absence of hypertension, heart failure or other disease states, and may be linked to the severity of OSA. The presence of clear-cut abnormalities in time and frequency-domain measures of blood-pressure and heart-rate variability in normotensive OSA patients provides intriguing evidence for the concept of an etiologic interaction between sleep apnea and cardiovascular disease. Mechanisms that could contribute to altered cardiovascular variability in patients with sleep apnea include abnormalities in chemoreflex, baroreflex and endothelial function.
KW - Autonomic nervous system
KW - Blood pressure
KW - Heart rate
KW - Sleep apnea
KW - Sympathetic nervous system
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U2 - 10.1016/S1566-0702(01)00272-7
DO - 10.1016/S1566-0702(01)00272-7
M3 - Article
C2 - 11485297
AN - SCOPUS:0035919971
SN - 1566-0702
VL - 90
SP - 89
EP - 94
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
IS - 1-2
ER -