Cardiovascular outcome in hospitalized patients with minimal troponin I elevation and normal creatine phosphokinase

Komandoor Srivathsan, John Showalter, James Wilkens, Brian Hurley, Amr Abbas, Hassan Loutfi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Among patients with acute coronary syndrome, elevated cardiac troponin and creatine phosphokinase MB fraction levels have both prognostic and diagnostic values. However, in hospitalized patients, cardiac biomarkers are measured in a variety of clinical situations including but not limited to acute coronary syndrome. Moreover, these patients may have elevated troponin levels with no increase in creatine phosphokinase MB fraction levels. Objective: To evaluate the cardiovascular outcome of acutely ill, hospitalized patients with minimal troponin I increase with normal creatine phosphokinase MB fraction. Methods: We identified 64 patients retrospectively from our database with minimal troponin I increase and normal creatine phosphokinase MB fraction hospitalized between November 1998 and April 2000. Discharged patients were questioned about re-hospitalization for myocardial infarction, unstable coronary syndrome, congestive heart failure and percutaneous coronary intervention by means of a structured questionnaire. For those patients who died during hospitalization, data were collected from hospital records. For patients who died at home or at a different institution, a surviving relative completed the questionnaire. Primary outcomes were death, myocardial infarction and the need for revascularization or re-hospitalization. Results: Composite endpoint of death, myocardial infarction, percutaneous coronary intervention or coronary artery bypass grafting and re-hospitalization for cardiac cause occurred in 35.95% of patients within 1 year. Conclusions: There is a significant composite event rate of death, myocardial infarction or re-hospitalization for cardiac causes in acutely ill, hospitalized patients with normal creatine phosphokinase MB fraction and minimally elevated troponin I, regardless of the cause for hospitalization.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalInternational Journal of Cardiology
Volume97
Issue number2
DOIs
StatePublished - Nov 1 2004

Keywords

  • Acute coronary syndrome
  • Creatine phosphokinase
  • Hospitalization
  • Myocardial infarction
  • Troponin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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