Cardiovascular implantable electronic

Talha Riaz, Juhsien J C Nienaber, Larry M. Baddour, Randall C. Walker, Soon J. Park, Muhammad Rizwan Sohail

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Most patients with left ventricular assist devices (LVADs) have concomitant cardiovascular implantable electronic devices (CIEDs). However, clinical presentation and outcome of CIED infection in the setting of LVAD has not been previously described. Methods We retrospectively reviewed 247 patients who underwent LVAD implantation at Mayo Clinic campuses in Minnesota, Arizona, and Florida, from January 2005 to December 2011. Demographic and clinical data of patients who met criteria for CIED infection were extracted. Results Of 247 patients with LVADs, 215 (87%) had CIED at the time of LVAD implantation and six (2.8%) subsequently developed CIED infections. Three patients developed CIED lead-related endocarditis and the other three had pocket infection. All three instances of CIED pocket infection were preceded by device generator exchange, whereas all three patients with CIED lead-related endocarditis had prior LVAD-related infections. Causative pathogens included Pseudomonas aeruginos (1), coagulase-negative staphylococci (2), methicillin-resistant Staphylococcus aureus (1), a gram-positive bacillus (1), and culture negative (2). All patients underwent complete CIED removal along with antimicrobial therapy. The three patients with CIED lead-related endocarditis and prior LVAD infections received chronic suppressive antibiotic therapy, and one patient had LVAD exchange. All but one remained alive at the last follow-up with a median duration of 15 months (7-46 months) from the time of CIED infection. Conclusion Patients who are receiving LVAD therapy and develop CIED infection should be managed with complete CIED removal. Chronic suppressive antibiotic therapy is warranted in cases that have concomitant LVAD infection.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Volume37
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Heart-Assist Devices
Equipment and Supplies
Infection
Endocarditis
Device Removal
Anti-Bacterial Agents
Coagulase
Therapeutics
Methicillin-Resistant Staphylococcus aureus
Pseudomonas
Staphylococcus
Bacillus
Demography

Keywords

  • congestive heart failure
  • CRT
  • defibrillation - ICD
  • heart transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Riaz, T., Nienaber, J. J. C., Baddour, L. M., Walker, R. C., Park, S. J., & Sohail, M. R. (2014). Cardiovascular implantable electronic. PACE - Pacing and Clinical Electrophysiology, 37(2), 225-230. https://doi.org/10.1111/pace.12240

Cardiovascular implantable electronic. / Riaz, Talha; Nienaber, Juhsien J C; Baddour, Larry M.; Walker, Randall C.; Park, Soon J.; Sohail, Muhammad Rizwan.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 37, No. 2, 02.2014, p. 225-230.

Research output: Contribution to journalArticle

Riaz, T, Nienaber, JJC, Baddour, LM, Walker, RC, Park, SJ & Sohail, MR 2014, 'Cardiovascular implantable electronic', PACE - Pacing and Clinical Electrophysiology, vol. 37, no. 2, pp. 225-230. https://doi.org/10.1111/pace.12240
Riaz T, Nienaber JJC, Baddour LM, Walker RC, Park SJ, Sohail MR. Cardiovascular implantable electronic. PACE - Pacing and Clinical Electrophysiology. 2014 Feb;37(2):225-230. https://doi.org/10.1111/pace.12240
Riaz, Talha ; Nienaber, Juhsien J C ; Baddour, Larry M. ; Walker, Randall C. ; Park, Soon J. ; Sohail, Muhammad Rizwan. / Cardiovascular implantable electronic. In: PACE - Pacing and Clinical Electrophysiology. 2014 ; Vol. 37, No. 2. pp. 225-230.
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abstract = "Background Most patients with left ventricular assist devices (LVADs) have concomitant cardiovascular implantable electronic devices (CIEDs). However, clinical presentation and outcome of CIED infection in the setting of LVAD has not been previously described. Methods We retrospectively reviewed 247 patients who underwent LVAD implantation at Mayo Clinic campuses in Minnesota, Arizona, and Florida, from January 2005 to December 2011. Demographic and clinical data of patients who met criteria for CIED infection were extracted. Results Of 247 patients with LVADs, 215 (87{\%}) had CIED at the time of LVAD implantation and six (2.8{\%}) subsequently developed CIED infections. Three patients developed CIED lead-related endocarditis and the other three had pocket infection. All three instances of CIED pocket infection were preceded by device generator exchange, whereas all three patients with CIED lead-related endocarditis had prior LVAD-related infections. Causative pathogens included Pseudomonas aeruginos (1), coagulase-negative staphylococci (2), methicillin-resistant Staphylococcus aureus (1), a gram-positive bacillus (1), and culture negative (2). All patients underwent complete CIED removal along with antimicrobial therapy. The three patients with CIED lead-related endocarditis and prior LVAD infections received chronic suppressive antibiotic therapy, and one patient had LVAD exchange. All but one remained alive at the last follow-up with a median duration of 15 months (7-46 months) from the time of CIED infection. Conclusion Patients who are receiving LVAD therapy and develop CIED infection should be managed with complete CIED removal. Chronic suppressive antibiotic therapy is warranted in cases that have concomitant LVAD infection.",
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N2 - Background Most patients with left ventricular assist devices (LVADs) have concomitant cardiovascular implantable electronic devices (CIEDs). However, clinical presentation and outcome of CIED infection in the setting of LVAD has not been previously described. Methods We retrospectively reviewed 247 patients who underwent LVAD implantation at Mayo Clinic campuses in Minnesota, Arizona, and Florida, from January 2005 to December 2011. Demographic and clinical data of patients who met criteria for CIED infection were extracted. Results Of 247 patients with LVADs, 215 (87%) had CIED at the time of LVAD implantation and six (2.8%) subsequently developed CIED infections. Three patients developed CIED lead-related endocarditis and the other three had pocket infection. All three instances of CIED pocket infection were preceded by device generator exchange, whereas all three patients with CIED lead-related endocarditis had prior LVAD-related infections. Causative pathogens included Pseudomonas aeruginos (1), coagulase-negative staphylococci (2), methicillin-resistant Staphylococcus aureus (1), a gram-positive bacillus (1), and culture negative (2). All patients underwent complete CIED removal along with antimicrobial therapy. The three patients with CIED lead-related endocarditis and prior LVAD infections received chronic suppressive antibiotic therapy, and one patient had LVAD exchange. All but one remained alive at the last follow-up with a median duration of 15 months (7-46 months) from the time of CIED infection. Conclusion Patients who are receiving LVAD therapy and develop CIED infection should be managed with complete CIED removal. Chronic suppressive antibiotic therapy is warranted in cases that have concomitant LVAD infection.

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