Cardiovascular effects of neurotension and some analogues on rats

Eugenio D. Di Paola, Elliott Richelson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

When administered in vivo into the femoral vein of normotensive rats, neurotensin, neurotensin-(8-13), and [D-Lys8]neurotensin-(8-13) decreased diastolic blood pressure in a dose-dependent manner, without change in heart rate. All three peptides evoked tachyphylaxis and a triphasic depressor-pressor-depressor, response at higher doses. The rank order of potency was neurotensin > [D-Lys8]neurotensin-(8-13). In organ chamber experiments, both neurotensin and neurotensin-(8-13) at a range of concentrations which induced dose-dependent decreases in blood pressure, did not significantly change tension in rat aorta rings with or without endothelium. In contrast, [D-Lys8]neurotensin-(8-13) induced weak dose-dependent relaxation of both rings with or without endothelium. However, this effect was not obtained at concentrations able to decrease the blood pressure. Indomethacin did not change the vasodilator effect of [D-Lys8]neurotensin-(8-13). There was no correlation between the vasodilator effect of this peptide and its ability to decrease blood pressure. These experiments suggest that the hypotension was not due to a direct vasodilator effect on the smooth muscle. In addition, since the rank order of peptide potency was opposite of those found in previous studies of second messenger synthesis and binding to neural tissue, these data suggest that there is a second receptor for neurotensin or that neurotensin can also bind to a different unknown receptor.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalEuropean Journal of Pharmacology
Volume175
Issue number3
DOIs
StatePublished - Jan 17 1990

Keywords

  • Aorta (rat)
  • Blood pressure
  • Heart rate
  • Neurotensin
  • Neurotensin analogues

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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