Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius

Robin A. Barraco, C. J. Janusz, P. M. Polasek, M. Parizon, P. A. Roberts

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Rats were anesthetized with urethane and limited occipital craniotomy was conducted to expose the caudal medulla in the region of the obex. Microinjections of adenosine were made into the nucleus tractus solitarius and heart rate and blood pressure responses recorded. Adenosine produced dose-related decreases in blood pressure and heart rate. The data indicate that adenosine may play a neuromodulatory role in central cardiovascular control areas.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalBrain Research Bulletin
Volume20
Issue number1
DOIs
StatePublished - Jan 1988

Keywords

  • Adenosine
  • Blood pressure
  • Heart rate
  • Nucleus tractus solitarius

ASJC Scopus subject areas

  • Neuroscience(all)

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